Factors predicting the instant effect of motor function after subthalamic nucleus deep brain stimulation in Parkinson's disease

被引:16
作者
Su, Xin-Ling [1 ]
Luo, Xiao-Guang [1 ]
Lv, Hong [1 ]
Wang, Jun [2 ]
Ren, Yan [1 ]
He, Zhi-Yi [1 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Neurol, 155 Nanjing North St, Shenyang 110001, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Neurosurg, Shenyang, Peoples R China
来源
TRANSLATIONAL NEURODEGENERATION | 2017年 / 6卷
关键词
Parkinson's disease; Deep brain stimulation; Subthalamic nucleus; Predictive factors; Levodopa responsiveness; FOLLOW-UP; ELECTRICAL-STIMULATION; ESTROGEN; LEVODOPA; OUTCOMES; EARLIER; COHORT; STAGE;
D O I
10.1186/s40035-017-0084-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson's disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies, however there were different conclusions about that through long-and short-term follow-ups. We aimed to investigate the factors which influence the predictive value of levodopa responsiveness, and discover more predictive factors of surgical outcomes. Methods: Twenty-three PD patients underwent bilateral STN-DBS and completed our follow-up. Clinical evaluations were performed 1 week before and 3 months after surgery. Results: STN-DBS significantly improved motor function of PD patients after 3 months; preoperative levodopa responsiveness and disease subtype predicted the effect of DBS on motor function; gender, disease duration and duration of motor fluctuations modified the predictive effect of levodopa responsiveness on motor improvement; the duration of motor fluctuations and severity of preoperative motor symptoms modified the predictive effect of disease subtype on motor improvement. Conclusions: The intensity of levodopa responsiveness served as a predictor of motor improvement more accurately in female patients, patients with shorter disease duration or shorter motor fluctuations; PD patients with dominant axial symptoms benefit less from STN-DBS compared to those with limb-predominant symptoms, especially in their later disease stage.
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页数:8
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