Association of the interleukin-10 gene-1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population

被引:8
作者
Li, W. Z. [1 ]
Gao, C. Y. [1 ]
He, W. L. [1 ]
Zhang, H. M. [1 ]
机构
[1] Xinxiang Cent Hosp, Dept Neurol, Xinxiang, Henan, Peoples R China
关键词
IL10-1082A/G; IL10-592C/A; Polymorphism; Ischemic stroke; SINGLE NUCLEOTIDE POLYMORPHISMS; PROMOTER; CORONARY; SUSCEPTIBILITY; METAANALYSIS;
D O I
10.4238/gmr.15017541
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated by polymerase chain reaction-restriction fragment length polymorphism. When compared with the control subjects, patients with ischemic stroke were more likely to be male, have a habit of tobacco smoking, have higher BMI, have hypertension or diabetes mellitus, and have higher levels of TC, LDL-C, HDL-C, and TG. The multivariate logistic regression analyses revealed that the AA genotype of IL10 -1082A/G was significantly associated with development of ischemic stroke in a Chinese population compared with the GG genotype (OR = 1.93, 95% CI = 1.15-3.25). In the dominant model, the association between GA+AA genotype of IL10 -1082A/G and risk of ischemic stroke was also significant compared with the GG genotype, and the adjusted OR (95% CI) for the GA+AA genotype was 1.41 (1.02-1.94). Thus, our study suggests that IL10 gene polymorphisms contribute to the development of ischemic stroke.
引用
收藏
页数:7
相关论文
共 50 条
  • [21] Relationship between Interleukin-10-1082A/G Polymorphism and Risk of Ischemic Stroke: A Meta-Analysis
    Jin, Jun
    Li, Wuying
    Peng, Lingmei
    Chen, Jian
    Li, Rong
    Wu, Peihua
    Tan, Sheng
    [J]. PLOS ONE, 2014, 9 (04):
  • [22] Interleukin-10-1082A/G polymorphism is associated with the development of acute pancreatitis in a Chinese population
    Cai, Feng
    Cui, Ning
    Ma, Hongyan
    Wang, Xueli
    Qiao, Guihong
    Liu, Danping
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (11): : 15170 - 15176
  • [23] Interleukin-10 gene-1082 G/A polymorphism in cervical cancer and cervical intraepithelial neoplasia: Meta-analysis
    Zhang, Shuo
    Kong, Ya-Lin
    Li, Ya-Li
    Yin, Yan-Wei
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2014, 42 (06) : 1193 - 1201
  • [24] Association of interleukin-10 polymorphism and malarial susceptibility in Pakistani population
    Afzal, Muhammad Sohail
    Ullah, Shakir
    Farooqi, Zia Ur Rehman
    Anjum, Sadia
    Shafi, Talha
    Ahmed, Tahir
    Ashraf, Muhammad
    Qadri, Ishtiaq
    [J]. ASIAN BIOMEDICINE, 2012, 6 (03) : 337 - 342
  • [25] Association of interleukin-10 gene polymorphisms with breast cancer in a Chinese population
    Kong, Fanjun
    Liu, Jie
    Liu, Yongheng
    Song, Bao
    Wang, Hualing
    Liu, Wenchao
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2010, 29
  • [26] Association of IL-10-1082A/G Polymorphism with Ischemic Stroke: Evidence from a Case-Control Study to an Updated Meta-Analysis
    Liu, Xu
    Li, Qu
    Zhu, Ruixia
    He, Zhiyi
    [J]. GENETIC TESTING AND MOLECULAR BIOMARKERS, 2017, 21 (06) : 341 - 350
  • [27] Relationship of Serum Interleukin-10 and Its Genetic Variations with Ischemic Stroke in a Chinese General Population
    Xie, Gaoqiang
    Myint, Phyo Kyaw
    Zaman, M. Justin S.
    Li, Ying
    Zhao, Liancheng
    Shi, Ping
    Ren, Fuxiu
    Wu, Yangfeng
    [J]. PLOS ONE, 2013, 8 (09):
  • [28] Association of Interleukin-10 Gene Polymorphism with Cachexia in Chinese Patients with Gastric Cancer
    Sun, Fengbo
    Sun, Yunbo
    Zhang, Dianliang
    Zhang, Jian
    Song, Bo
    Zheng, Hongmei
    [J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2010, 40 (02) : 149 - 155
  • [29] Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population
    Huang, Jingyan
    Wei, Qiugui
    Liang, Baoyun
    Shen, Tingting
    Wu, Yanli
    Chen, Ziwen
    Yang, Junwei
    Gu, Lian
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2021, 88 : 271 - 276
  • [30] Investigation of the association between Interleukin-10 polymorphisms and risk of acute pancreatitis in a Chinese population
    Jia, H. L.
    Sun, P. L.
    Lu, C. Q.
    [J]. GENETICS AND MOLECULAR RESEARCH, 2015, 14 (04) : 15876 - 15881