Flavonoids and biological activities of Jussiaea repens

被引：43
作者：
Marzouk, M. S.
Soliman, F. M.
Shehata, I. A.
Rabee, M.
Fawzy, G. A.
机构：
[1] Natl Res Ctr, Chem Tannins & Leather Technol Dept, Cairo, Egypt
[2] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt
[3] Theodor Bilharz Res Inst, Giza, Egypt
来源：
NATURAL PRODUCT RESEARCH | 2007年 / 21卷 / 05期
关键词：
Jussiaea repens; Onagraceae; aerial parts; quercetin and kaempferol 3-O-glycosides; hepatoprotective activity; anti-inflammatory activity; antidiabetic activity;
D O I：
10.1080/14786410600943288
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new acylated avicularin, namely avicularin 200-(4000-O-n- pentanoyl)- gallate ( 1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. ( Onagraceae). Their structures were established as trifolin 2"-O-gallate ( 2), quercetrin ( 3), guaijaverin ( 4), reynoutrin ( 5), juglanin ( 6), avicularin ( 7), hyperin ( 8), trifolin ( 9), hyperin 2"-O-gallate ( 10), rutin ( 11), kaempferol ( 12) and quercetin ( 13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD50 up to the maximum soluble dose 4 g kg(-1) body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.
引用
收藏
页码：436 / 443
页数：8
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