Discovery of long-sought light-gated potassium channels: natural kalium channel-rhodopsins

被引：0
|
作者：
Spudich, John L. [1 ]
Govorunova, Elena G. [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
来源：
NATURE NEUROSCIENCE | 2022年 / 25卷 / 07期
关键词：
D O I：
10.1038/s41593-022-01096-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We report light-gated channels in a fungus-like protist that are highly selective for K+ over Na+. These microbial rhodopsin channels, named kalium channelrhodopsins, enable robust inhibition of mouse cortical neurons with millisecond precision. In addition, kalium channelrhodopsins reveal a previously unknown potassium selectivity mechanism.
引用
收藏
页码：847 / 847
页数：1
相关论文
共 17 条
  • [1] Discovery of long-sought light-gated potassium channels: natural kalium channel-rhodopsins
    Nature Neuroscience, 2022, 25 : 847 - 848
  • [2] Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
    Govorunova, Elena G.
    Gou, Yueyang
    Sineshchekov, Oleg A.
    Li, Hai
    Lu, Xiaoyu
    Wang, Yumei
    Brown, Leonid S.
    St-Pierre, Francois
    Xue, Mingshan
    Spudich, John L.
    NATURE NEUROSCIENCE, 2022, 25 (07) : 967 - +
  • [3] Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
    Elena G. Govorunova
    Yueyang Gou
    Oleg A. Sineshchekov
    Hai Li
    Xiaoyu Lu
    Yumei Wang
    Leonid S. Brown
    François St-Pierre
    Mingshan Xue
    John L. Spudich
    Nature Neuroscience, 2022, 25 : 967 - 974
  • [4] Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics
    Govorunova, Elena G.
    Sineshchekov, Oleg A.
    Janz, Roger
    Liu, Xiaoqin
    Spudich, John L.
    SCIENCE, 2015, 349 (6248) : 647 - 650
  • [5] Engineering of a light-gated potassium channel
    Cosentino, Cristian
    Alberio, Laura
    Gazzarrini, Sabrina
    Aquila, Marco
    Romano, Edoardo
    Cermenati, Solei
    Zuccolini, Paolo
    Petersen, Jan
    Beltrame, Monica
    Van Etten, James L.
    Christie, John M.
    Thiel, Gerhard
    Moroni, Anna
    SCIENCE, 2015, 348 (6235) : 707 - 710
  • [6] Engineering of a Light-Gated Potassium Channel
    Moroni, Anna
    Alberio, Laura
    Romano, Edoardo
    Cermenati, Solei
    Beltrame, Monica
    Thiele, Gerhard
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 6A - 6A
  • [7] Engineering of a light-gated potassium channel
    Alberio, L.
    Cosentino, C.
    Gazzarrini, S.
    Aquila, M.
    Romano, E.
    Cermenati, S.
    Zuccolini, P.
    Petersen, J.
    Beltrame, M.
    van Etten, J. L.
    Christie, J. M.
    Thiel, G.
    Moroni, A.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015, 44 : S212 - S212
  • [8] Light-gated potassium channels from nature
    Rita Strack
    Nature Methods, 2022, 19 : 923 - 923
  • [9] Light-gated potassium channels from nature
    Strack, Rita
    NATURE METHODS, 2022, 19 (08) : 923 - 923
  • [10] Viral rhodopsins 1 are an unique family of light-gated cation channels
    Dmitrii Zabelskii
    Alexey Alekseev
    Kirill Kovalev
    Vladan Rankovic
    Taras Balandin
    Dmytro Soloviov
    Dmitry Bratanov
    Ekaterina Savelyeva
    Elizaveta Podolyak
    Dmytro Volkov
    Svetlana Vaganova
    Roman Astashkin
    Igor Chizhov
    Natalia Yutin
    Maksim Rulev
    Alexander Popov
    Ana-Sofia Eria-Oliveira
    Tatiana Rokitskaya
    Thomas Mager
    Yuri Antonenko
    Riccardo Rosselli
    Grigoriy Armeev
    Konstantin Shaitan
    Michel Vivaudou
    Georg Büldt
    Andrey Rogachev
    Francisco Rodriguez-Valera
    Mikhail Kirpichnikov
    Tobias Moser
    Andreas Offenhäusser
    Dieter Willbold
    Eugene Koonin
    Ernst Bamberg
    Valentin Gordeliy
    Nature Communications, 11
12