Synergistic effects of pravastatin and pioglitazone in renal tubular epithelial cells induced by transforming growth factor-β1

被引：8
作者：
Wei, Jia-li
Ma, Chun-yang
Zhang, Yang-De [1 ]
Li, Yiming
机构：
[1] Minist Hlth, Natl Key Lab Nanobiol Technol, Changsha 410008, Peoples R China
[2] Hainan Med Coll, Dept Neurosurg, Affiliated Hosp, Haikou 510008, Hainan, Peoples R China
[3] Kagawa Univ, Fac Med, Dept Cardio Renal & Cerebrovasc Med, Kagawa, Japan
[4] Xi An Jiao Tong Univ, Sch Med, Dept Physiol, Xian 710049, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2007年 / 31卷 / 05期
关键词：
peroxisome proliferator-activated receptor-gamma agonist; statin; transforming growth factor-beta 1; alpha-smooth muscle actin; connective tissue growth factor; fibronectin; plasminogen activator inhibitor-1; collagen; 1; human renal proximal tubular epithelial cell;
D O I：
10.1016/j.cellbi.2006.11.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent studies suggest that treatment with PPAR-gamma agonists and statins have beneficial effects on renal disease. However, the combined effects of PPAR-gamma agonists and statins in human renal epithelial cells are unknown. Our present study revealed that there were synergistic effects of pravastatin and pioglitazone in the expression of alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), fibronectin (FN), plasminogen activator inhibitor-1 (PAI-1) and collagen 1 in human renal proximal tubular epithelial cells induced by transforming growth factor-beta 1 (TGF-beta 1). The beneficial effects of combined therapy against renal tubular epithelial cell injury are attributed, at least in part, to the inhibition of transdifferentiation, extracellular matrix deposition and cytokine production. (C) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：451 / 458
页数：8
相关论文
共 57 条
[21]   TGF-β1 activates MAP kinase in human mesangial cells:: A possible role in collagen expression [J].
Hayashida, T ;
Poncelet, AC ;
Hubchak, SC ;
Schnaper, HW .
KIDNEY INTERNATIONAL, 1999, 56 (05) :1710-1720
[22]   Peroxisome proliferator-activated receptor gamma agonists in renal disease [J].
Iglesias, Pedro ;
Diez, Juan J. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2006, 154 (05) :613-621
[23]   Role of mitogen-activated protein kinases as downstream effectors of transforming growth factor-β in mesangial cells [J].
Inoki, K ;
Haneda, M ;
Ishida, T ;
Mori, H ;
Maeda, S ;
Koya, D ;
Sugimoto, T ;
Kikkawa, R .
KIDNEY INTERNATIONAL, 2000, 58 :S76-S80
[24]   Evidence that fibroblasts derive from epithelium during tissue fibrosis [J].
Iwano, M ;
Plieth, D ;
Danoff, TM ;
Xue, C ;
Okada, H ;
Neilson, EG .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (03) :341-350
[25]   Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates renal injury in an experimental model of ischemia-reperfusion [J].
Joyce, M ;
Kelly, C ;
Winter, D ;
Chen, G ;
Leahy, A ;
Bouchier-Hayes, D .
JOURNAL OF SURGICAL RESEARCH, 2001, 101 (01) :79-84
[26]  
Kim SI, 2000, J AM SOC NEPHROL, V11, P80, DOI 10.1681/ASN.V11180
[27]   Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells [J].
Lan, HY .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2003, 12 (01) :25-29
[28]   Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity:: SB-431542 [J].
Laping, NJ ;
Grygielko, E ;
Mathur, A ;
Butter, S ;
Bomberger, J ;
Tweed, C ;
Martin, W ;
Fornwald, J ;
Lehr, R ;
Harling, J ;
Gaster, L ;
Callahan, JF ;
Olson, BA .
MOLECULAR PHARMACOLOGY, 2002, 62 (01) :58-64
[29]   Rosiglitazone ameliorates cisplatin-induced renal injury in mice [J].
Lee, Sik ;
Kim, Won ;
Moon, Sang-Ok ;
Sung, Mi Jeong ;
Kim, Duk Hoon ;
Kang, Kyung Pyo ;
Jang, Yong Bum ;
Lee, Jung Eun ;
Jang, Kyu Yun ;
Park, Sung Kwang .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (08) :2096-2105
[30]  
LEE SK, 1993, NEPHROL DIAL TRANSPL, V8, P1338
123456