Techniques and technologies for the bioanalysis of Sativex®, metabolites and related compounds

被引：6

作者：

Molnar, Anna ^{[1
]}

Fu, Shanlin ^{[1
]}

机构：

[1] Univ Technol Sydney, Ctr Forens Sci, Ultimo, NSW 2007, Australia

来源：

BIOANALYSIS | 2016年 / 8卷 / 08期

关键词：

cannabidiol; Sativex (R); tetrahydrocannabinol; TANDEM MASS-SPECTROMETRY; CONTROLLED SMOKED CANNABIS; THC/CBD OROMUCOSAL SPRAY; SOLID-PHASE EXTRACTION; IN-VITRO STABILITY; ORAL FLUID; WHOLE-BLOOD; SIMULTANEOUS QUANTIFICATION; HUMAN URINE; GLUCURONIDATED CANNABINOIDS;

D O I：

10.4155/bio-2015-0021

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Sativex (R) is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains Delta(9)-tetrahydrocannabinol (THC) and cannabidiol in an approximately 1: 1 ratio. The increasing prevalence of medicinal cannabis products highlights the importance of reliable bioanalysis and re-evaluation of the interpretation of positive test results for THC, as legal implications may arise in workplace, roadside and sports drug testing situations. This article summarizes published research on the bioanalysis of THC and cannabidiol, with particular focus on Sativex. Common screening and confirmatory testing of blood, urine, oral fluid and hair samples are outlined. Correlations between matrices and current analytical pitfalls are also addressed.

引用

页码：829 / 845

页数：17

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