TGF-β in renal development and renal growth

被引：14

作者：

Basile, DP

Hammerman, MR

机构：

[1] Washington Univ, Sch Med, George M Obrien Kidney & Urol Dis Ctr, Dept Internal Med,Renal Div, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, George M Obrien Kidney & Urol Dis Ctr, Dept Cell Biol,Renal Div, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, George M Obrien Kidney & Urol Dis Ctr, Dept Physiol,Renal Div, St Louis, MO 63110 USA

来源：

MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 2-3期

关键词：

acute renal failure; bone morphogenetic protein; metanephrogenesis; TGF-beta;

D O I：

10.1159/000057362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Organogenesis of the metanephric kidney is regulated by a number of polypeptide growth factors, Members of the TGF-beta family of growth factors have been shown to be produced in kidney during its development, Available evidence suggests that some of these members play key roles in metanephrogenesis by regulating the process of ureteric bud arborization, The regeneration of the S-3 segment of the proximal tubule that occurs following ischemic injury recapitulates in many ways the renal developmental paradigm. The expression of TGF-beta in regenerating kidney is tightly regulated postischemia. We suggest that TGF-beta plays a key role in the repair process following injury and mediates some of the cellular events common to both regeneration and nephrogenesis.

引用

页码：144 / 148

页数：5

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