Chronic circadian disruption on a high-fat diet impairs glucose tolerance

被引：17

作者：

Zitting, Kirsi-Marja ^{[1
,2
,3
]}

Vetrivelan, Ramalingam ^{[3
,4
,5
,6
]}

Yuan, Robin K. ^{[1
,2
,3
]}

Vujovic, Nina ^{[1
,2
,3
]}

Wang, Wei ^{[1
,2
,3
]}

Bandaru, Sathyajit S. ^{[3
,4
,5
,6
]}

Quan, Stuart F. ^{[1
,2
,3
]}

Klerman, Elizabeth B. ^{[1
,2
,3
,9
,10
]}

Scheer, Frank A. J. L. ^{[1
,2
,3
]}

Buxton, Orfeu M. ^{[1
,2
,3
,7
]}

Williams, Jonathan S. ^{[6
,8
]}

Duffy, Jeanne F. ^{[1
,2
,3
]}

Saper, Clifford B. ^{[3
,4
,5
,6
]}

Czeisler, Charles A. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Neurol, Div Sleep & Circadian Disorders, Boston, MA 02115 USA

[3] Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA

[4] Beth Israel Deaconess Med Ctr, Dept Neurol, Program Neurosci, Boston, MA 02215 USA

[5] Beth Israel Deaconess Med Ctr, Div Sleep Med, Boston, MA 02215 USA

[6] Harvard Med Sch, Boston, MA 02215 USA

[7] Dept Biobehav Hlth, University Pk, PA 16802 USA

[8] Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA

[9] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[10] Harvard Med Sch, Boston, MA 02114 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2022年 / 130卷

基金：

美国国家卫生研究院;

关键词：

Recurrent circadian disruption; Glucose tolerance; Insulin sensitivity; High-fat diet; Weight gain; Shift work; METABOLIC SYNDROME; INSULIN SENSITIVITY; ENERGY-EXPENDITURE; SLEEP-DEPRIVATION; BLOOD-PRESSURE; SHIFT WORK; OBESITY; HEALTHY; MISALIGNMENT; RESTRICTION;

D O I：

10.1016/j.metabol.2022.155158

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Nearly 14% of Americans experience chronic circadian disruption due to shift work, increasing their risk of obesity, diabetes, and other cardiometabolic disorders. These disorders are also exacerbated by modern eating habits such as frequent snacking and consumption of high-fat foods. Methods: We investigated the effects of recurrent circadian disruption (RCD) on glucose metabolism in C57BL/6 mice and in human participants exposed to non-24-h light-dark (LD) schedules vs. those on standard 24-h LD schedules. These LD schedules were designed to induce circadian misalignment between behaviors including rest/activity and fasting/eating with the output of the near-24-h central circadian pacemaker, while minimizing sleep loss, and were maintained for 12 weeks in mice and 3 weeks in humans. We examined interactions of these circadian-disrupted schedules compared to control 24-h schedules with a lower-fat diet (LFD, 13% in mouse and 25-27% in humans) and high-fat diet (HFD, 45% in mouse and 45-50% in humans). We also used young vs. older mice to determine whether they would respond differently to RCD. Results: When combined with a HFD, we found that RCD caused significant weight gain in mice and increased body fat in humans, and significantly impaired glucose tolerance and insulin sensitivity in both mice and humans, but this did not occur when RCD was combined with a LFD. This effect was similar in both young and older mice. Conclusion: These results in both humans and a model organism indicate that circadian disruption has an adverse effect on metabolism among individuals eating a high-fat Western-style diet, even in the absence of significant sleep loss, and suggest that reducing dietary fat may protect against the metabolic consequences of a lifestyle (such as shift work) that involves chronic circadian disruption.

引用

页数：14

共 69 条

[41] Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers [J].