Application of a double Mannich reaction using bis(aminol) ethers in the synthesis of AE ring analogues of methyl lycaconitine

被引：24
作者：
Brocke, C
Brimble, MA
Lin, DSH
McLeod, MD
机构：
[1] Univ Auckland, Dept Chem, Auckland, New Zealand
[2] Univ Sydney, Sch Chem, Camperdown, NSW 2006, Australia
来源：
SYNLETT | 2004年 / 13期
关键词：
Mannich reaction; aminoalkylation; bis(aminol) ethers; methyl lycaconitine; alkaloids;
D O I：
10.1055/s-2004-831340
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes is reported via double Mannich reaction of cyclic ketoesters with bis(aminol) ethers. This method is applied to the synthesis of AE ring analogues of methyl lycaconitine.
引用
收藏
页码：2359 / 2363
页数：5
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