Unrelated Umbilical Cord Blood Transplantation and Immune Reconstitution

被引：53

作者：

Szabolcs, Paul ^{[2
,3
]}

Cairo, Mitchell S. ^{[1
]}

机构：

[1] Columbia Univ, New York Presbyterian Hosp, Morgan Stanley Childrens Hosp, Div Pediat Blood & Marrow Transplantat, New York, NY 10032 USA

[2] Duke Univ, Med Ctr, Dept Pediat, Div Pediat Bone Marrow Transplantat, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Immunol, Durham, NC USA

来源：

SEMINARS IN HEMATOLOGY | 2010年 / 47卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; VERSUS-HOST-DISEASE; EX-VIVO EXPANSION; BONE-MARROW-TRANSPLANTATION; PERIPHERAL T-CELLS; NATURAL-KILLER; MONONUCLEAR-CELLS; REGULATORY CELLS; LYMPHOID MALIGNANCIES; ADOPTIVE TRANSFER;

D O I：

10.1053/j.seminhematol.2009.10.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review highlights the unique features of immune reconstitution following unrelated cord blood transplantation (UCBT) that lead to heightened risk of infection-related mortality in the early post-UCBT period. There is no evidence that innate immunity is uniquely compromised after UCBT, but the development of antigen-specific cellular immunity is affected by numerical and qualitative deficits, primarily within the first 100 days. Nevertheless, beyond the first few months after UCBT there is no evidence for reduced graft-versus-leukemia (GVL) or anti-viral immunity compared to other hematopoietic cell therapy (HCT) modalities. Novel cellular therapies that are about to enter the clinical setting in the form of natural killer (NK) cell and T-cell therapies in the form of donor lymphocyte infusion (DLI) are also discussed. Semin Hematol 47:22-36. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：22 / 36

页数：15

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