Centrosome biogenesis and function: centrosomics brings new understanding

被引:418
作者
Bettencourt-Dias, Monica
Glover, David M.
机构
[1] Gulbenkian Inst Sci, Cell Cycle Regulat Lab, P-2780156 Oeiras, Portugal
[2] Univ Cambridge, Dept Genet, Canc Res UK Cell Cycle Genet Grp, Cambridge CB2 3EH, England
关键词
D O I
10.1038/nrm2180
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Centrosomes, which were first described in the late 19th century, are found in most animal cells and undergo duplication once every cell cycle so that their number remains stable, like the genetic material of a cell. However, their function and regulation have remained elusive and controversial. Only recently has some understanding of these fundamental aspects of centrosome function and biogenesis been gained through the concerted application of genomics and proteomics, which we term ` centrosomics'. The identification of new molecules has highlighted the evolutionary conservation of centrosome function and provided a conceptual framework for understanding centrosome behaviour and how it can go awry in human disease.
引用
收藏
页码:451 / 463
页数:13
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