Copper-Catalyzed Sulfonyl Radical-Enabled Regioselective Cyclization of 1,6-Enynes

被引：16

作者：

Zhang, Jun-Yao ^{[1
]}

Bao, Wen-Hui ^{[1
]}

Qin, Fu-Hua ^{[1
]}

Lei, Ke-Wei ^{[1
]}

Li, Qiang ^{[2
]}

Wei, Wen-Ting ^{[1
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

[2] Liaocheng Univ, Inst Funct Organ Mol & Mat, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Copper; radical cascade cyclization; 1; 6-enynes; sulfonyl hydrazides; CARBONYL ALKYL BROMIDES; METAL-FREE; CASCADE SYNTHESIS; VINYL SULFONES; HYDRAZIDES; ALCOHOLS; ALKENES; SULFONYLHYDRAZIDES; FUNCTIONALIZATION; 1,7-ENYNES;

D O I：

10.1002/ajoc.201900539

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed cascade cyclization of 1,6-enynes with sulfonyl hydrazides for producing various sulfonyl-substituted gamma-lactams is described. This sulfonyl radical-enabled cyclization reaction features excellent regioselectivity, mild conditions and broad substrate scope, enabling the formation of new C-S and C-C bonds through radical sulfonylation, intramolecular cyclization and hydrogen abstraction. Moreover, relevant experiments have been carried out to probe a possible mechanism.

引用

页码：2050 / 2053

页数：4

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