The potential role of nucleophosmin (NPM1) in the development of cancer

被引：51

作者：

Karimi Dermani, Fateme ^{[1
,2
]}

Gholamzadeh Khoei, Saeideh ^{[1
,3
]}

Afshar, Saeid ^{[1
]}

Amini, Razieh ^{[1
]}

机构：

[1] Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Hamadan, Iran

[2] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

[3] Hamadan Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Hamadan, Hamadan, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2021年 / 236卷 / 11期

关键词：

cancer; NPM1; nucleophosmin; tumorigenesis; leukemia; solid tumors; ACUTE MYELOID-LEUKEMIA; FAVORABLE PROGNOSTIC IMPACT; INTERNAL TANDEM DUPLICATION; TRANS-RETINOIC ACID; GENE-MUTATIONS; PROTEIN B23; MULTIFUNCTIONAL PROTEIN; RIBOSOME BIOGENESIS; FLT3-ITD MUTATIONS; NUCLEAR EXPORT;

D O I：

10.1002/jcp.30406

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nucleophosmin (NPM1) is a well-known nucleocytoplasmic shuttling protein that performs several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic stability, cell cycle progression, and apoptosis. NPM1 has been identified to be necessary for normal cellular functions, and its altered regulation by overexpression, mutation, translocation, loss of function, or sporadic deletion can lead to cancer and tumorigenesis. In this review, we focus on the gene and protein structure of NPM1 and its physiological roles. Finally, we discuss the association of NPM1 with various types of cancer including solid tumors and leukemia.

引用

页码：7832 / 7852

页数：21

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