Seasonal variation of respiratory viral infections: a comparative study between children with cancer undergoing chemotherapy and children without cancer

被引:4
作者
Dror, Tal [1 ]
Akerman, Meredith [2 ]
Noor, Asif [1 ,3 ,4 ]
Weinblatt, Mark E. [1 ,5 ,6 ]
Islam, Shahidul [2 ]
Glasser, Chana L. [1 ,4 ]
机构
[1] NYU, Dept Pediat, Langone Hosp Long Isl, 259 1st St, Mineola, NY 11501 USA
[2] NYU, Dept Biostat, Langone Hosp Long Isl, Mineola, NY 11501 USA
[3] NYU, Dept Pediat Infect Dis, Langone Hosp Long Isl, Mineola, NY 11501 USA
[4] NYU, Dept Pediat Infect Dis, Long Isl Sch Med, Mineola, NY 11501 USA
[5] NYU, Langone Hosp Long Isl, Dept Pediat Hematol Oncol, Mineola, NY 11501 USA
[6] NYU, Long Isl Sch Med, Dept Pediat Hematol Oncol, Mineola, NY 11501 USA
关键词
Cancer; epidemiology; infectious disease; pediatric oncology; respiratory virus;
D O I
10.1080/08880018.2020.1871137
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Respiratory viral infections (RVIs) affect children year-round, with seasonal-specific patterns. Pediatric oncology patients are uniquely vulnerable to infection, but whether this predisposes them to different patterns of RVIs than healthy children is unknown. There is also limited data on the impact of RVIs on cancer patients. We conducted a retrospective study of children ages 1-21 with cancer presenting to the clinic and emergency department (ED) and a randomly selected subset of patients without cancer presenting to the ED who had positive nasopharyngeal viral polymerase chain reactions at our institution from 2014 to 2019. Sixty-seven cancer patients (206 RVI episodes) and 225 pediatric non-cancer patients (237 RVI episodes) were included. Human rhino/enterovirus (HRE) was the most common infection in both groups in the spring, summer, and fall. In the winter, the most common RVI was influenza in cancer patients verses respiratory syncytial virus in non-cancer patients. On age-adjusted analysis, the likelihood of detecting coronavirus in the winter, HRE in the spring and fall, and parainfluenza in the summer was significantly greater in cancer patients (OR = 2.60, 2.52, 5.73, 3.59 respectively). Among cancer RVI episodes, 50% received parenteral antibiotics, 22% were severely neutropenic, 22% had chemotherapy delays for a median of six days, 16% were hospitalized, and 6% received intravenous immunoglobulin. We conclude that there are differences in the seasonal patterns of RVIs between children with and without cancer. RVIs also cause significant morbidity in children with cancer.
引用
收藏
页码:444 / 455
页数:12
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