Catalytic hydrogen-mediated cross-coupling of enones and carbonyl compounds: Aldol condensation by hydrogenation

被引:37
作者
Jang, HY [1 ]
Krische, MJ [1 ]
机构
[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA
关键词
hydrogenation; rhodium catalysis; aldol reaction; cross-coupling; transition metal enolate;
D O I
10.1002/ejoc.200400270
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Catalytic hydrogenation of enones and enals in the presence of aldehyde and ketone partners results in the formation of aldol products. A key feature of such hydrogen-mediated C-C bond formations relates to the heterolytic activation of elemental hydrogen by cationic rhodium(i) complexes, that enables monohydride-based catalytic cycles for which direct alkyl-hydrogen reductive elimination pathways are disabled. Here, a concise over-view of catalytic hydrogen-mediated aldol condensation is presented.
引用
收藏
页码:3953 / 3958
页数:6
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