Anti-microbial activity of a new vaginal contraceptive NIM-76 from neem oil (Azadirachta indica)

被引：74

作者：

SaiRam, M ^{[1
]}

Ilavazhagan, G

Sharma, SK

Dhanraj, SA

Suresh, B

Parida, MM

Jana, AM

Devendra, K

Selvamurthy, W

机构：

[1] Minist Def, Def Inst Physiol & Allied Sci, Delhi 110054, India

[2] Def Res & Dev Estab, Gwalior 474002, India

[3] JSS Coll Pharm, Rocklands, Ooty, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 71卷 / 03期

关键词：

NIM-76; contraceptive; anti-microbial activity;

D O I：

10.1016/S0378-8741(99)00211-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Efficacy of NIM-76, a spermicidal fraction from neem oil, was investigated for its antimicrobial action against certain bacteria, fungi and Polio virus as compared to whole neem oil. The NIM-76 preparation showed stronger anti-microbial activity than the whole neem oil. It inhibited growth of various Pathogens tested including Escherichia coli and Kleibsiella pneumoniae which were not affected by the whole neem oil. NIM-76 also exhibited antifungal activity against Candida albicans and antiviral activity against Polio virus replication in vero cell lines. It also protected mice from systemic candidiasis as revealed by enhanced % survival and reduced colony forming units of C. albicans in various tissues. This shows that NIM-76 has a potent broad spectrum anti-microbial activity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：377 / 382

页数：6

共 22 条

[1]

[Anonymous], NEEM RES DEV

[2]

Binde N.K., 1958, INDIAN J MED SCI, V12, P141

[3]

Chopra R. N., 1956, GLOSSARY INDIAN MED, P31

[4]

FUZIWARA T, 1982, CHEM PHARM BULL, V30, P4025

[5] Antimicrobial activity of Annatto (Bixa orellana) extract [J].

Irobi, ON ;

MooYoung, M ;

Anderson, WA .

INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1996, 34 (02) :87-90

[6]

KAIIAKAMB M, 1992, PHARM ACTA HELVETICA, V67, P130

[7]

Khan M., 1987, Natural pesticides from the neem tree (Azadirachta indica A. Juss) and other tropical plants. Proceedings of the 3rd International Neem Conference, Nairobi, Kenya, 10-15 July 1986., P645

[8] Antimutagenic and anticarcinogenic potentials of some Thai vegetables [J].

Kusamran, WR ;

Tepsuwan, A ;

Kupradinun, P .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 402 (1-2) :247-258

[9]

Okpanyi S. N., 1981, PLANTA MED, V56, P111

[10]

PATEL RP, 1962, INDIAN J MED RES, V5, P218

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