Antidiabetic Drugs in the Treatment of Alzheimer's Disease

被引：40

作者：

Michailidis, Michalis ^{[1
]}

Tata, Despina A. ^{[2
]}

Moraitou, Despina ^{[2
]}

Kavvadas, Dimitrios ^{[3
]}

Karachrysafi, Sofia ^{[3
]}

Papamitsou, Theodora ^{[3
]}

Vareltzis, Patroklos ^{[4
]}

Papaliagkas, Vasileios ^{[5
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Psychol, Lab Psychol, Thessaloniki 54124, Greece

[2] Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki 54124, Greece

[3] Aristotle Univ Thessaloniki, Fac Med, Histol & Embryol Dept, Thessaloniki 54124, Greece

[4] Aristotle Univ Thessaloniki, Dept Chem Engn, Thessaloniki 54124, Greece

[5] Int Hellen Univ, Sch Hlth Sci, Dept Biomed Sci, Thessaloniki 57400, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 09期

关键词：

amyloid beta; Alzheimer type 3 diabetes mellitus; intranasal insulin; metformin; type 2 diabetes mellitus; incretins; PPAR gamma agonists; thiazolidinediones; MILD COGNITIVE IMPAIRMENT; GLUCAGON-LIKE PEPTIDE-1; GAMMA AGONIST PIOGLITAZONE; INTRANASAL INSULIN THERAPY; ACTIVATED RECEPTOR-GAMMA; GROWTH-FACTOR EXPRESSION; PPAR-GAMMA; AMYLOID-BETA; TAU HYPERPHOSPHORYLATION; MEMORY IMPAIRMENT;

D O I：

10.3390/ijms23094641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The public health burden of type 2 diabetes mellitus and Alzheimer's disease is steadily increasing worldwide, especially in the population of older adults. Epidemiological and clinical studies suggest a possible shared pathophysiology between the two diseases and an increased risk of AD in patients with type 2 diabetes mellitus. Therefore, in recent years, there has been a substantial interest in identifying the mechanisms of action of antidiabetic drugs and their potential use in Alzheimer's disease. Human studies in patients with mild cognitive impairment and Alzheimer's disease have shown that administration of some antidiabetic medications, such as intranasal insulin, metformin, incretins, and thiazolidinediones, can improve cognition and memory. This review aims to examine the latest evidence on antidiabetic medications as a potential candidate for the treatment of Alzheimer's disease.

引用

页数：17

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