PRESENCE OF HEPATITIS B VIRUS IN PARAFFIN-EMBEDDED LIVER TISSUES OF PATIENTS WITH HEPATOCELLULAR CARCINOMA

被引：0
作者：
Sa-nguanmoo, Pattaratida [1 ]
Chittmittraprap, Salyavit [2 ]
Tangkijvanich, Pisit [2 ]
Wisedopas, Naruemon [3 ]
Poovorawan, Yong [1 ]
机构：
[1] Chulalongkorn Univ, Ctr Excellence Clin Virol, Bangkok, Thailand
[2] Chulalongkorn Univ, Ctr Excellence Hepatitis & Liver Canc, Bangkok, Thailand
[3] Chulalongkorn Univ, Fac Med, Dept Pathol, Bangkok, Thailand
来源：
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH | 2020年 / 51卷 / 03期
关键词：
hepatitis B virus; hepatocellular carcinoma; liver cell differentiation stage; liver tissue; mutation; CORE PROMOTER; PRE-S; MUTATIONS; RISK; DNA; QUANTIFICATION; PRECORE/CORE; ASSOCIATION; INFECTION;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
There are limited virological data regarding hepatitis B virus in liver tissues of hepatocellular carcinoma (HCC) patients. The study examined correlation between virological data and HCC status in 76 HCC patients classified into HBV infection status, genotype, mutation, and HBV DNA and covalently closed circular DNA (cccDNA) copies/cell. Genotype C was the most prevalent (70%); deletion of preS1 was present in 43% and novel C1673G/A and C1773T/A in 62% of region 3 mutations of HBV samples sequenced. Stage of liver cell differentiation stage, serological status of HCC patients and HBV genotype were strongly associated with preS deletion (p-value <0.001). Functional nature of these findings awaits further investigation.
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页码：366 / 374
页数：9
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