Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017

被引：135

作者：

Ndumbi, Patricia ^{[1
,4
]}

Freidl, Gudrun S. ^{[1
,5
]}

Williams, Christopher J. ^{[1
,2
]}

Mardh, Otilia ^{[3
]}

Varela, Carmen ^{[4
]}

Avellon, Ana ^{[4
]}

Friesema, Ingrid ^{[5
]}

Vennema, Harry ^{[5
]}

Beebeejaun, Kazim ^{[6
]}

Ngui, Siew Lin ^{[6
]}

Edelstein, Michael ^{[6
]}

Smith-Palmer, Alison ^{[7
]}

Murphy, Niamh ^{[8
]}

Dean, Jonathan ^{[9
]}

Faber, Mirko ^{[10
]}

Wenzel, Juergen ^{[11
]}

Kontio, Mia ^{[12
]}

Muller, Luise ^{[13
]}

Midgley, Sofie Elisabeth ^{[13
]}

Sundqvist, Lena ^{[14
]}

Ederth, Josefine Lundberg ^{[14
]}

Roque-Afonso, Anne-Marie ^{[15
]}

Couturier, Elisabeth ^{[16
]}

Klamer, Sofieke ^{[17
]}

Rebolledo, Javiera ^{[17
]}

Suin, Vanessa ^{[17
]}

Aberle, Stephan W. ^{[18
]}

Schmid, Daniela ^{[19
]}

De Sousa, Rita ^{[20
]}

Augusto, Goncalo Figueiredo ^{[21
]}

Alfonsi, Valeria ^{[22
]}

Del Manso, Martina ^{[22
]}

Ciccaglione, Anna Rita ^{[22
]}

Mellou, Kassiani ^{[23
]}

Hadjichristodoulou, Christos ^{[24
]}

Donachie, Alastair ^{[1
,25
]}

Borg, Maria-Louise ^{[25
]}

Socan, Maja ^{[26
]}

Poljak, Mario ^{[27
]}

Severi, Ettore ^{[3
]}

机构：

[1] European Ctr Dis Prevent & Control, EPIET, Solna, Sweden

[2] Publ Hlth Wales, Cardiff, S Glam, Wales

[3] European Ctr Dis Prevent & Control, Solna, Sweden

[4] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain

[5] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[6] Publ Hlth England Colindale, London, England

[7] Hlth Protect Scotland, Glasgow, Lanark, Scotland

[8] Hlth Protect Surveillance Ctr, Dublin, Ireland

[9] Natl Virus Reference Lab, Dublin, Ireland

[10] Robert Koch Inst, Berlin, Germany

[11] Univ Hosp Regensburg, Regensburg, Germany

[12] Natl Inst Hlth & Welf THL, Helsinki, Finland

[13] Statens Serum Inst, Copenhagen, Denmark

[14] Publ Hlth Agcy Sweden, Stockholm, Sweden

[15] Ctr Natl Reference Virus Hepatites Transmiss Ente, Villejuif, France

[16] Sante Publ France, St Maurice, France

[17] Sciensano, Brussels, Belgium

[18] Med Univ Vienna, Vienna, Austria

[19] Austrian Agcy Hlth & Food Safety, Vienna, Austria

[20] Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal

[21] Directorate Gen Hlth, Lisbon, Portugal

[22] Inst Super Sanita, Rome, Italy

[23] Hellen Ctr Dis Control, Athens, Greece

[24] Univ Thessaly, Larisa, Greece

[25] Hlth Promot & Dis Prevent Directorate, Msida, Malta

[26] Natl Inst Publ Hlth, Ljubljana, Slovenia

[27] Univ Ljubljana, Ljubljana, Slovenia

来源：

EUROSURVEILLANCE | 2018年 / 23卷 / 33期

基金：

美国国家卫生研究院;

关键词：

VIRUS;

D O I：

10.2807/1560-7917.ES.2018.23.33.1700641

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Between 1 June 2016 and 31 May 2017, 17 European Union (EU) and European Economic Area countries reported 4,096 cases associated with a multi-country hepatitis A (HA) outbreak. Molecular analysis identified three co-circulating hepatitis A virus (HAV) strains of genotype IA: VRD_521_ 2016, V16-25801 and RIVM-HAV16-090. We categorised cases as confirmed, probable or possible, according to the EU outbreak case definitions. Confirmed cases were infected with one of the three outbreak strains. We investigated case characteristics and strain-specific risk factors for transmission. A total of 1,400 (34%) cases were confirmed; VRD_521_ 2016 and RIVM-HAV16-090 accounted for 92% of these. Among confirmed cases with available epidemiological data, 92% (361/393) were unvaccinated, 43% (83/195) travelled to Spain during the incubation period and 84% (565/676) identified as men who have sex with men (MSM). Results depict an HA outbreak of multiple HAV strains, within a cross-European population, that was particularly driven by transmission between non-immune MSM engaging in high-risk sexual behaviour. The most effective preventive measure to curb this outbreak is HAV vaccination of MSM, supplemented by primary prevention campaigns that target the MSM population and promote protective sexual behaviour.

引用

页码：2 / 13

页数：12

共 29 条

[1]

[Anonymous], 2012, Wkly Epidemiol Rec, V87

[2]

[Anonymous], 1999, MMWR Recomm Rep, V48, P1

[3]

[Anonymous], SEX TRANSM INF INCL

[4] Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017 [J].

Beebeejaun, K. ;

Degala, S. ;

Balogun, K. ;

Simms, I. ;

Woodhall, S. C. ;

Heinsbroek, E. ;

Crook, P. D. ;

Kar-Purkayastha, I. ;

Treacy, J. ;

Wedgwood, K. ;

Jordan, K. ;

Mandal, S. ;

Ngui, S. L. ;

Edelstein, M. .

EUROSURVEILLANCE, 2017, 22 (05) :7-12

[5] Trends in infectious diseases and the male to female ratio: Possible clues to changes in behavior among men who have sex with men [J].

Beltrami, JF ;

Shouse, RL ;

Blake, PA .

AIDS EDUCATION AND PREVENTION, 2005, 17 (06) :49-59

[6] Monophyletic outbreak of Hepatitis A involving HIV-infected men who have sex with men, Rome, Italy 2008-2009 [J].

Bordi, Licia ;

Rozera, Gabriella ;

Scognamiglio, Paola ;

Minosse, Claudia ;

Loffredo, Mariarosaria ;

Antinori, Andrea ;

Narciso, Pasquale ;

Ippolito, Giuseppe ;

Girardi, Enrico ;

Capobianchi, Maria Rosaria .

JOURNAL OF CLINICAL VIROLOGY, 2012, 54 (01) :26-29

[7] Seroprevalence and susceptibility to hepatitis A in the European Union and European Economic Area: a systematic review [J].

Carrillo-Santisteve, Paloma ;

Tavoschi, Lara ;

Severi, Ettore ;

Bonfigli, Sandro ;

Edelstein, Michael ;

Bystrom, Emma ;

Lopalco, Pierluigi .

LANCET INFECTIOUS DISEASES, 2017, 17 (10) :E306-E319

[8]

Centers for Disease Control and Prevention (CDC), 1992, MMWR-MORBID MORTAL W, V41, P15561

[9] Hepatitis A outbreak in HIV-infected MSM and in PrEP-using MSM despite a high level of immunity, Lyon, France, January to June 2017 [J].

Charre, Caroline ;

Ramiere, Christophe ;

Roque-Afonso, Anne-Marie ;

Chidiac, Christian ;

Zoulim, Fabien ;

Godinot, Matthieu ;

Koffi, Joseph ;

Scholtes, Caroline ;

Livrozet, Jean-Michel ;

Cotte, Laurent .

EUROSURVEILLANCE, 2017, 22 (48) :11-14

[10] Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015-2016: observations from a tertiary medical center [J].

Chen, Nan-Yu ;

Liu, Zhuo-Hao ;

Shie, Shian-Sen ;

Chen, Tsung-Hsing ;

Wu, Ting-Shu .

BMC INFECTIOUS DISEASES, 2017, 17

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