Direct catalytic cross-coupling of alkenyllithium compounds

被引：54

作者：

Hornillos, Valentin ^{[1
]}

Giannerini, Massimo ^{[1
]}

Vila, Carlos ^{[1
]}

Fananas-Mastral, Martin ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL SCIENCE | 2015年 / 6卷 / 02期

基金：

欧洲研究理事会;

关键词：

ORGANOLITHIUM COMPOUNDS; ORTHO-METALATION; ORGANIC HALIDES; CARBON-CARBON; PALLADIUM; ARYL; REAGENTS; STRATEGY; ACETYLATION; VINYLATION;

D O I：

10.1039/c4sc03117b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd-2(dba)(3)/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions. In addition (1-ethoxyvinyl) lithium can be efficiently converted into substituted vinyl ethers which, after hydrolysis, give readily access to the corresponding methyl ketones in a one pot procedure.

引用

页码：1394 / 1398

页数：5

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