Exosomes: Carriers of Pro-Fibrotic Signals and Therapeutic Targets in Fibrosis

被引:30
作者
Li, Mengyu [1 ,3 ]
Jiang, Mao [1 ,3 ]
Meng, Jie [1 ,3 ]
Tao, Lijian [2 ,3 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Resp & Crit Care Med, 932 Lushans Rd, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China
[3] Cent South Univ, Organ Fibrosis Res Ctr, 932 Lushans Rd, Changsha, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
Exosomes; fibrosis; hepatic stellate cells; macrophages; epithelials; fibrocite; podocyte; mesenchymal stem cell; HEPATIC STELLATE CELLS; MESENCHYMAL STEM-CELLS; TISSUE GROWTH-FACTOR; TUBULAR EPITHELIAL-CELLS; DRUG-DELIVERY VEHICLES; EXTRACELLULAR VESICLES; LIVER FIBROSIS; T-CELLS; MACROPHAGE POLARIZATION; MOLECULAR-MECHANISMS;
D O I
10.2174/1381612825666191209161443
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Exosomes are nano-sized extracellular vesicles that are released by a variety of cells. Exosomes contain cargo from cells they derived, including lipids, proteins and nucleic acids. The bilayer lipid membrane structure of exosomes protects these contents from degradation, allowing them for intercellular communication. The role of exosomes in fibrotic diseases is increasingly being valued. Exosomes, as carriers of profibrotic signals, are involved in the development of fibrotic diseases, and also regulate fibrosis by transmitting signals that inhibit fibrosis or inflammation. Exosomes mobilize and activate a range of effector cells by targeted delivery of bioactive information. Exosomes can also reflect the condition of cells, tissues and organisms, and thus become potential biomarkers of fibrotic diseases. Exosomes from bone marrow stem cells support biological signaling that regulates and inhibits fibrosis and thus initially used in the treatment of fibrotic diseases. This article briefly summarizes the role of exosomes in the pathogenesis and treatment of fibrotic diseases and raises some issues that remain to be resolved.
引用
收藏
页码:4496 / 4509
页数:14
相关论文
共 50 条
[11]   The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting [J].
Romano, Eloisa ;
Rosa, Irene ;
Fioretto, Bianca Saveria ;
Matucci-Cerinic, Marco ;
Manetti, Mirko .
CURRENT MOLECULAR MEDICINE, 2022, 22 (03) :209-239
[12]   MSC-sEV Treatment Polarizes Pro-Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH [J].
Zhang, Bin ;
Zhang, Biyan ;
Lai, Ruenn Chai ;
Sim, Wei Kian ;
Lam, Kong Peng ;
Lim, Sai Kiang .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
[13]   Novel Therapeutic Targets in Liver Fibrosis [J].
Zhang, Jinhang ;
Liu, Qinhui ;
He, Jinhan ;
Li, Yanping .
FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
[14]   O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts [J].
Very, Ninon ;
Boulet, Clemence ;
Gheeraert, Celine ;
Berthier, Alexandre ;
Johanns, Manuel ;
Bou Saleh, Mohamed ;
Guille, Loic ;
Bray, Fabrice ;
Strub, Jean-Marc ;
Bobowski-Gerard, Marie ;
Zummo, Francesco P. ;
Vallez, Emmanuelle ;
Molendi-Coste, Olivier ;
Woitrain, Eloise ;
Cianferani, Sarah ;
Montaigne, David ;
Ntandja-Wandji, Line Carolle ;
Dubuquoy, Laurent ;
Dubois-Chevalier, Julie ;
Staels, Bart ;
Lefebvre, Philippe ;
Eeckhoute, Jerome .
CELL DEATH & DISEASE, 2024, 15 (06)
[15]   An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action [J].
Rankin, A. C. ;
Hendry, B. M. ;
Corcoran, J. P. ;
Xu, Q. .
BRITISH JOURNAL OF PHARMACOLOGY, 2013, 170 (06) :1177-1189
[16]   Endoplasmic reticulum stress as a pro-fibrotic stimulus [J].
Tanjore, Harikrishna ;
Lawson, William E. ;
Blackwell, Timothy S. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2013, 1832 (07) :940-947
[17]   Mechanisms of fibrosis: therapeutic translation for fibrotic disease [J].
Wynn, Thomas A. ;
Ramalingam, Thirumalai R. .
NATURE MEDICINE, 2012, 18 (07) :1028-1040
[18]   COBALT IONS STIMULATE A FIBROTIC RESPONSE THROUGH MATRIX REMODELLING, FIBROBLAST CONTRACTION AND RELEASE OF PRO-FIBROTIC SIGNALS FROM MACROPHAGES [J].
Xu, J. ;
Nyga, A. ;
Li, W. ;
Zhang, X. ;
Gavara, N. ;
Knight, M. M. ;
Shelton, J. C. .
EUROPEAN CELLS & MATERIALS, 2018, 36 :142-155
[19]   Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration [J].
Lu, Ye ;
Mai, Zizhao ;
Cui, Li ;
Zhao, Xinyuan .
STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
[20]   The pro-fibrotic effects of pregnancy in a carbon-tetrachloride-induced liver injury in mouse model [J].
Amer, Johnny ;
Grifat, Rami ;
Doron, Sarit ;
Abu-Tair, Lina ;
Mruwat, Rufayda ;
El-Khatib, Areej ;
Safadi, Rifaat .
LIVER INTERNATIONAL, 2014, 34 (08) :1232-1240