Integrating Physical and Molecular Insights on Immune Cell Migration

被引：67

作者：

Moreau, Helene D. ^{[1
]}

Piel, Matthieu ^{[2
,3
]}

Voituriez, Raphael ^{[4
]}

Lennon-Dumenil, Ana-Maria ^{[1
]}

机构：

[1] Inst Curie, INSERM, U932, ANR-10-IDEX-0001-02 PSL & ANR-11-LABX-0043, Paris, France

[2] PSL Res Univ, Inst Curie, CNRS, UMR 144, F-75005 Paris, France

[3] PSL Res Univ, Inst Pierre Gilles Gennes, F-75005 Paris, France

[4] UPMC, Lab Jean Perrin, CNRS, UM 8237, 4 Pl Jussieu, F-75005 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 08期

关键词：

MYOSIN-IIA; T-CELLS; DENDRITIC CELLS; NUCLEAR-DEFORMATION; LEUKOCYTE MIGRATION; GUIDED MIGRATION; ACTIN FLOWS; IN-VIVO; ADHESION; MOTILITY;

D O I：

10.1016/j.it.2018.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The function of most immune cells depends on their ability to migrate through complex microenvironments, either randomly to patrol for the presence of antigens or directionally to reach their next site of action. The actin cytoskeleton and its partners are key conductors of immune cell migration as they control the intrinsic migratory properties of leukocytes as well as their capacity to respond to cues present in their environment. In this review we focus on the latest discoveries regarding the role of the actomyosin cytoskeleton in optimizing immune cell migration in complex environments, with a special focus on recent insights provided by physical modeling.

引用

页码：632 / 643

页数：12

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