Familial Aggregation of Maxillary Lateral Incisor Agenesis

被引：24

作者：

Pinho, T.

Maciel, P. ^{[2
]}

Lemos, C. ^{[1
,2
,3
]}

Sousa, A. ^{[1
,3
]}

机构：

[1] Univ Porto, ICBAS, Dept Populat Studies, P-4099003 Oporto, Portugal

[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

[3] Inst Mol & Cell Biol, UnIGENe, Oporto, Portugal

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 06期

关键词：

hypodontia; microdontia; maxillary lateral incisors; relative risk; familial aggregation; SELECTIVE TOOTH AGENESIS; PERMANENT TEETH; MISSENSE MUTATION; MOLAR OLIGODONTIA; HYPODONTIA; MSX1; PREVALENCE; PAX9; GENE; MALOCCLUSION;

D O I：

10.1177/0022034510364486

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

In spite of recent developments, data regarding the genes responsible for the less severe forms of hypodontia are still scarce and controversial. This study addressed the hypothesis that agenesis of maxillary lateral incisors (MLIA) is a distinct type of hypodontia, by evaluating its familial aggregation and the occurrence of other types of ageneses or microdontia in probands' relatives. Sixty-two probands with MLIA were identified, and information was collected on 142 first-degree relatives. Relative risk (RR) was calculated and compared by re-assessment of data previously published for the Swedish, Utah, and Israeli populations, for the same trait. A RR of 15 was obtained in the Portuguese, 16 in the Swedish, 12 in Utah, and 5 in the Israeli population. Our results support a significant familial aggregation of MLIA, show that MLIA almost never segregates with other forms of agenesis, and suggest that microdontia of maxillary lateral incisors is part of the same phenotype.

引用

页码：621 / 625

页数：5