Anxiety in Parkinson?s disease: A resting-state high density EEG study

被引：13

作者：

Betrouni, Nacim ^{[1
]}

Alazard, Edouard ^{[2
]}

Bayot, Madli ^{[1
,2
]}

Carey, Guillaume ^{[1
,3
]}

Derambure, Philippe ^{[1
,2
]}

Defebvre, Luc ^{[1
,3
]}

Leentjens, Albert Fg ^{[4
]}

Delval, Arnaud ^{[1
,2
]}

Dujardin, Kathy ^{[1
,3
]}

机构：

[1] Univ Lille, Degenerat & Vasc Cognit Disorders, U1172, CHU Lille,INSERM, F-59000 Lille, France

[2] CHU Lille, Clin Neurophysiol Dept, F-59000 Lille, France

[3] CHU Lille, Neurol & Movement Disorders Dept, F-59000 Lille, France

[4] Maastricht Univ, Med Ctr, Maastricht, Netherlands

来源：

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY | 2022年 / 52卷 / 03期

关键词：

Anxiety disorders; Electroencephalo-graphy; Functional connectivity; Spectral analysis; ALPHA-OSCILLATIONS; FUNCTIONAL CONNECTIVITY; RATING-SCALE; DISORDER; VALIDATION; CORRELATE; SYSTEM; CORTEX;

D O I：

10.1016/j.neucli.2022.01.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To identify markers of Parkinson & rsquo;s disease (PD) related anxiety, using high density electroencephalography (hd-EEG). Methods: 108 patients participated in the study. They were divided into two groups: with and without clinically relevant anxiety, according to their score on the Parkinson Anxiety Scale. Resting-state hd-EEG was recorded. Spectral and functional connectivity characteristics were compared between the two groups. Results: Thirty-three patients (31%) had significant anxiety symptoms. In the spectral analysis, relative power in the alpha1 frequency band in the right prefrontal cortex was lower in patients with anxiety than without. Functional connectivity analysis showed a stronger connectivity between the left insula and several regions of the right prefrontal cortex in patients with anxiety than in those without. Conclusion: This study shows the pivotal role of the insula and frontal cortex in the pathophysiology of anxiety in PD and extends the results of previous studies using magnetic resonance imaging or positron emission tomography imaging. (c) 2022 Elsevier Masson SAS. All rights reserved.

引用

页码：202 / 211

页数：10

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[1]

[Anonymous], 1976, Geriatric psychiatry

[2] FUNDAMENTALS OF ELECTROENCEFALOGRAPHY, MAGNETOENCEFALOGRAPHY, AND FUNCTIONAL MAGNETIC RESONANCE IMAGING [J].