Effect of HLA matching on outcome of related and unrelated donor transplantation therapy for chronic myelogenous leukemia

被引：10
作者：
Petersdorf, E
Anasetti, C
Servida, P
Martin, P
Hansen, J
机构：
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
[2] Univ Washington, Sch Med, Seattle, WA USA
[3] Osped San Raffaele, Bone Marrow Transplant Unit, Milan, Italy
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1998年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0889-8588(05)70499-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This article examines the diversity and biologic role of human lymphocyte antigen (HLA) genes as related to marrow transplantation for chronic myelogenous leukemia (CML). A better understanding of the nature and function of HLA variation is necessary as unrelated marrow transplantation evolves into a safe and effective treatment for CML. HLA matching is an important aspect of donor selection criteria and has a role in engraft-ment as well as the development of graft-versus-host disease and tolerance after transplant.
引用
收藏
页码：107 / +
页数：16
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