Carboxybetaine polymer-protected gold nanoparticles: High dispersion stability and resistance against non-specific adsorption of proteins

被引：69
作者：
Matsuura, Kazuhiro
Ohno, Kohji
Kagaya, Shigehiro
Kitano, Hiromi [1 ]
机构：
[1] Toyama Univ, Dept Appl Chem, Grad Sch Sci & Engn, Toyama 9308555, Japan
[2] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2007年 / 208卷 / 08期
关键词：
atom transfer radical polymerization (ATRP); gold nanoparticles; NMR; non-specific adsorption; polymer brush; zwitterionic polymer;
D O I：
10.1002/macp.200600652
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
1-Carboxy-N,N-dimethyl-N-(2'-methacryloyloxyethyl)methanaminium inner salt (CMB) was polymerized by ATRP initiated with a disulfide difunctionalized by 2-bromoisobutyryl groups. The disulfide-carrying carboxybetaine polymer (DT-PCMB) was used for the preparation of PCMB-protected gold nanoparticles (PCMB-AuNPs) obtained by the reduction of hydrogen tetrachloroaurate (HAuCl4) in the presence of the DT-PCMB of different molecular weights at different molar ratios of DT-PCMB and HAuCl4. The sizes of gold cores in the PCMB-AuNPs tended to increase upon decreasing concentration and molecular weight of the DT-PCMB. The PCMB-AuNPs possessed a high dispersion stability, and showed a resistance against non-specific adsorption of proteins (bovine serum albumin, human serum albumin, lysozyme, and cytochrome c). Therefore, DT-PCMB is a quite suitable stabilizing ligand to prepare inert AuNPs and the PCMB-AuNPs will be useful in biomedical applications.
引用
收藏
页码：862 / 873
页数：12
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