Autoantibody screening in subacute cerebellar ataxia

被引:21
作者
Trivedi, R [1 ]
Mundanthanam, G [1 ]
Amyes, E [1 ]
Lang, B [1 ]
Vincent, A [1 ]
机构
[1] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Dept Clin Neurol, Oxford OX3 9DS, England
关键词
D O I
10.1016/S0140-6736(00)02585-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a retrospective study of 280 sera from patients presenting with cerebellar signs, seven of whom had proved positive for the typical paraneoplastic serum antibodies that were requested by the clinicians, raised concentrations of antibodies to voltage-gated calcium channels or to glutamic acid decarboxylase were detected in a further seven sera. Systematic screening for these and other antibodies in future cases should help in the diagnosis and management of the patients.
引用
收藏
页码:565 / 566
页数:2
相关论文
共 5 条
  • [1] Dalmau J, 1999, BRAIN PATHOL, V9, P275
  • [2] Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia
    Hadjivassiliou, M
    Grünewald, R
    Chattopadhyay, AK
    Davies-Jones, GAB
    Gibson, A
    Jarratt, JA
    Kandler, RH
    Lobo, A
    Powell, T
    Smith, CML
    [J]. LANCET, 1998, 352 (9140) : 1582 - 1585
  • [3] Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome
    Mason, WP
    Graus, F
    Lang, B
    Honnorat, J
    Delattre, JY
    Valldeoriola, F
    Antoine, JC
    Rosenblum, MK
    Rosenfeld, MR
    NewsomDavis, J
    Posner, JB
    Dalmau, J
    [J]. BRAIN, 1997, 120 : 1279 - 1300
  • [4] SAIZ A, 1999, NEUROLOGY, V52, P857
  • [5] Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor
    Smitt, PS
    Kinoshita, A
    De Leeuw, B
    Moll, W
    Coesmans, M
    Jaarsma, D
    Henzen-Logmans, S
    Vecht, C
    De Zeeuw, C
    Sekiyama, N
    Nakanishi, S
    Shigemoto, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (01) : 21 - 27