Inflammatory osteolysis: a conspiracy against bone

被引：185

作者：

Mbalaviele, Gabriel ^{[1
]}

Novack, Deborah V. ^{[1
,2
]}

Schett, Georg ^{[3
]}

Teitelbaum, Steven L. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Bone & Mineral Dis, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Anat & Mol Pathol, St Louis, MO 63110 USA

[3] Univ Erlangen Nurnberg, Dept Internal Med 3, Rheumatol & Immunol, Erlangen, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2017年 / 127卷 / 06期

关键词：

NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FAMILIAL MEDITERRANEAN FEVER; C-REACTIVE PROTEIN; RHEUMATOID-ARTHRITIS; OSTEOCLAST DIFFERENTIATION; PORPHYROMONAS-GINGIVALIS; FACTOR-ALPHA; TNF-ALPHA;

D O I：

10.1172/JCI93356

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorptive cell or do so indirectly via cytokine arrest. Despite these advances, a substantial number of patients with inflammatory arthritis remain resistant to current therapies, and even effective anti-inflammatory drugs frequently do not repair damaged bone. Thus, insights into events such as those impacted by inflammasomes, which signal through cytokine-dependent and -independent mechanisms, are needed to optimize treatment of inflammatory osteolysis.

引用

页码：2030 / 2039

页数：10

共 185 条

[51] Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes [J].

Feldmann, J ;

Prieur, AM ;

Quartier, P ;

Berquin, P ;

Certain, S ;

Cortis, E ;

Teillac-Hamel, D ;

Fischer, A ;

de Saint Basile, G .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (01) :198-203

[52] Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study [J].

Finzel, Stephanie ;

Rech, Juergen ;

Schmidt, Sarah ;

Engelke, Klaus ;

Englbrecht, Matthias ;

Schett, Georg .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (03) :396-400

[53] The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures [J].

Fitzpatrick, R. E. ;

Campbell, P. D. ;

Sivagurunathan, S. ;

Pagel, C. N. ;

Potempa, J. ;

Mackie, E. J. ;

Pike, R. N. .

JOURNAL OF PERIODONTAL RESEARCH, 2009, 44 (04) :565-567

[54] Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1 [J].

Gao, Yayi ;

Tang, Jiayou ;

Chen, Weiqian ;

Li, Qiang ;

Nie, Jia ;

Lin, Fang ;

Wu, Qingsi ;

Chen, Zuojia ;

Gao, Zhimei ;

Fan, Huimin ;

Tsun, Andy ;

Shen, Jijia ;

Chen, Guihua ;

Liu, Zhongmin ;

Lou, Zhenkun ;

Olsen, Nancy J. ;

Zheng, Song Guo ;

Li, Bin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (25) :E3246-E3254

[55] IFN-γ stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation [J].

Gao, Yuhao ;

Grassi, Francesco ;

Ryan, Michaela Robbie ;

Terauchi, Masakazu ;

Page, Karen ;

Yang, Xiaoying ;

Weitzmann, M. Neale ;

Pacifici, Roberto .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) :122-132

[56]

Gravallese EM, 1998, AM J PATHOL, V152, P943

[57] Staphylococcal Strains Vary Greatly in Their Ability to Induce an Inflammatory Response in Endothelial Cells [J].

Grundmeier, Matthias ;

Tuchscherr, Lorena ;

Brueck, Michaela ;

Viemann, Dorothee ;

Roth, Johannes ;

Willscher, Edith ;

Becker, Karsten ;

Peters, Georg ;

Loeffler, Bettina .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (06) :871-880

[58] Inflammasomes: mechanism of action, role in disease, and therapeutics [J].

Guo, Haitao ;

Callaway, Justin B. ;

Ting, Jenny P-Y .

NATURE MEDICINE, 2015, 21 (07) :677-687

[59] NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis [J].

Gurung, Prajwal ;

Burton, Amanda ;

Kanneganti, Thirumala-Devi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (16) :4452-4457

[60] Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement [J].

Hajishengallis, George ;

Liang, Shuang ;

Payne, Mark A. ;

Hashim, Ahmed ;

Jotwani, Ravi ;

Eskan, Mehmet A. ;

McIntosh, Megan L. ;

Alsam, Asil ;

Kirkwood, Keith L. ;

Lambris, John D. ;

Darveau, Richard P. ;

Curtis, Michael A. .

CELL HOST & MICROBE, 2011, 10 (05) :497-506

← 1 2 3 4 5 6 7 8 9 10 →