Inflammatory osteolysis: a conspiracy against bone

被引：185
作者：
Mbalaviele, Gabriel [1 ]
Novack, Deborah V. [1 ,2 ]
Schett, Georg [3 ]
Teitelbaum, Steven L. [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, Div Bone & Mineral Dis, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Anat & Mol Pathol, St Louis, MO 63110 USA
[3] Univ Erlangen Nurnberg, Dept Internal Med 3, Rheumatol & Immunol, Erlangen, Germany
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2017年 / 127卷 / 06期
关键词：
NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FAMILIAL MEDITERRANEAN FEVER; C-REACTIVE PROTEIN; RHEUMATOID-ARTHRITIS; OSTEOCLAST DIFFERENTIATION; PORPHYROMONAS-GINGIVALIS; FACTOR-ALPHA; TNF-ALPHA;
D O I：
10.1172/JCI93356
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorptive cell or do so indirectly via cytokine arrest. Despite these advances, a substantial number of patients with inflammatory arthritis remain resistant to current therapies, and even effective anti-inflammatory drugs frequently do not repair damaged bone. Thus, insights into events such as those impacted by inflammasomes, which signal through cytokine-dependent and -independent mechanisms, are needed to optimize treatment of inflammatory osteolysis.
引用
收藏
页码：2030 / 2039
页数：10
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