Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer

被引:43
作者
Wu, Yingjie [1 ,2 ]
Jamal, Muhammad [1 ]
Xie, Tian [1 ]
Sun, Jiaxing [1 ]
Song, Tianbao [1 ]
Yin, Qian [1 ]
Li, Jingyuan [1 ]
Pan, Shan [1 ]
Zeng, Xingruo [1 ]
Xie, Songping [3 ]
Zhang, Qiuping [1 ,4 ]
机构
[1] Wuhan Univ, Sch Basic Med Sci, Dept Immunol, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Dept Pathol, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ, Dept Thorac Surg, Renmin Hosp, Wuhan, Hubei, Peoples R China
[4] Wuhan Univ, Hubei Prov Key Lab Developmentally Originated Dis, Wuhan, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
biomarker; early diagnosis; lung cancer; prognosis; uridine-cytidine kinase 2; NUCLEOSIDE ANALOGS; GENE-EXPRESSION; CELLS; ADENOCARCINOMA; INHIBITION; STATISTICS; METABOLISM; REVEALS;
D O I
10.1111/cas.14125
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lung cancer has the highest morbidity and mortality among all cancers. Discovery of early diagnostic and prognostic biomarkers of lung cancer can greatly facilitate the survival rate and reduce its mortality. In our study, by analyzing Gene Expression Omnibus and Oncomine databases, we found a novel potential oncogene uridine-cytidine kinase 2 (UCK2), which was overexpressed in lung tumor tissues compared to adjacent nontumor tissues or normal lung. Then we confirmed this finding in clinical samples. Specifically, UCK2 was identified as highly expressed in stage IA lung cancer with a high diagnostic accuracy (area under the receiver operating characteristic curve > 0.9). We also found that high UCK2 expression was related to poorer clinicopathological features, such as higher T stage and N stage and higher probability of early recurrence. Furthermore, we found that patients with high UCK2 expression had poorer first progression survival and overall survival than patients with low UCK2 expression. Univariate and multivariate Cox regression analyses showed that UCK2 was an independent risk factor related with worse DFS and OS. By gene set enrichment analysis, tumor-associated biological processes and signaling pathways were enriched in the UCK2 overexpression group, which indicated that UCK2 might play a vital role in lung cancer. Furthermore, in cytology experiments, we found that knockdown of UCK2 could suppress the proliferation and migration of lung cancer cells. In conclusion, our study indicated that UCK2 might be a potential early diagnostic and prognostic biomarker for lung cancer.
引用
收藏
页码:2734 / 2747
页数:14
相关论文
共 50 条
[41]   LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer [J].
Zhang, Qiudan ;
Shen, Jinze ;
Wu, Yuchen ;
Ruan, Wenjing ;
Zhu, Feng ;
Duan, Shiwei .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[42]   Altered Serum Annexin A2 Might Be a New Potential Diagnostic Biomarker in Human Colorectal Cancer [J].
Hu, Daojun ;
Shen, Baoyan ;
Yu, Miao ;
Zha, Xiaoyin ;
Zhou, Ye ;
Chen, Feng ;
Ren, Jianlin ;
Zhang, Li .
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2020, 50 (06) :726-733
[43]   Prediction and verification of the prognostic biomarker SLC2A2 and its association with immune infiltration in gastric cancer [J].
Zhang, Weijian ;
Zhou, Dishu ;
Song, Shuya ;
Hong, Xinxin ;
Xu, Yifei ;
Wu, Yuqi ;
Li, Shiting ;
Zeng, Sihui ;
Huang, Yanzi ;
Chen, Xinbo ;
Liang, Yizhong ;
Guo, Shaoju ;
Pan, Huafeng ;
Li, Haiwen .
ONCOLOGY LETTERS, 2024, 27 (02)
[44]   Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma [J].
Wang, Bo ;
Wang, Wei ;
Zhu, ZhiZhong ;
Zhang, XueBin ;
Tang, Fan ;
Wang, Dong ;
Liu, Xi ;
Yan, XiaoLing ;
Zhuang, Hao .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2017, 154 :28-33
[45]   Expression of GM2 Activator Protein as a Potential Biomarker for Lung Cancer [J].
Pottprommanee, Laddawan ;
Boonyapranai, Kongsak ;
Sangthong, Padchanee ;
Chewaskulyong, Busyamas ;
Chen, Shui-Tein ;
Shank, Lalida .
JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) :S719-S719
[46]   CDK1 serves as a potential prognostic biomarker and target for lung cancer [J].
Li, Mingyao ;
He, Fenyi ;
Zhang, Zhanchun ;
Xiang, Zhenfei ;
Hu, Danfei .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2020, 48 (02)
[47]   Kinase inhibitor screening reveals aurora-a kinase is a potential therapeutic and prognostic biomarker of gastric cancer [J].
Mesquita, Felipe P. ;
Lucena da Silva, Emerson ;
Souza, Pedro F. N. ;
Lima, Luina B. ;
Amaral, Jackson L. ;
Zuercher, William ;
Albuquerque, Louise M. ;
Rabenhorst, Silvia H. B. ;
Moreira-Nunes, Caroline A. ;
Amaral de Moraes, Maria E. ;
Montenegro, Raquel C. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2021, 122 (10) :1376-1388
[48]   CircRNAs as promising biomarker in diagnostic and prognostic of lung cancer: An updated meta-analysis [J].
Yang, Xianglin ;
Tian, Wen ;
Wang, Shen ;
Ji, Xiaotong ;
Zhou, Baosen .
GENOMICS, 2021, 113 (01) :387-397
[49]   IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer [J].
Li, Jiang-jiang ;
Li, Ruilei ;
Wang, Wenxiang ;
Zhang, Baihua ;
Song, Xin ;
Zhang, Chunfang ;
Gao, Yang ;
Liao, Qianjin ;
He, Ya ;
You, Shuo ;
Tan, Zheqiong ;
Luo, Xiangjian ;
Li, Yueshuo ;
Tang, Min ;
Weng, Xinxian ;
Yi, Wei ;
Peng, Shifang ;
Liu, Shaohui ;
Tan, Ying ;
Bode, Ann M. ;
Cao, Ya .
MOLECULAR ONCOLOGY, 2018, 12 (05) :602-610
[50]   Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients [J].
Jens Köhler ;
Martin Schuler ;
Thomas Christoph Gauler ;
Stefanie Nöpel-Dünnebacke ;
Maike Ahrens ;
Andreas-Claudius Hoffmann ;
Stefan Kasper ;
Felix Nensa ;
Benedikt Gomez ;
Maria Hahnemann ;
Frank Breitenbuecher ;
Danjouma Cheufou ;
Filiz Özkan ;
Kaid Darwiche ;
Mathias Hoiczyk ;
Henning Reis ;
Stefan Welter ;
Wilfried Ernst Erich Eberhardt ;
Martin Eisenacher ;
Helmut Teschler ;
Georgios Stamatis ;
Wolff Schmiegel ;
Stephan Albrecht Hahn ;
Alexander Baraniskin .
Journal of Cancer Research and Clinical Oncology, 2016, 142 :795-805