Role of Hypoxia in the Control of the Cell Cycle

被引：26

作者：

Druker, Jimena ^{[1
]}

Wilson, James W. ^{[2
]}

Child, Fraser ^{[2
]}

Shakir, Dilem ^{[2
]}

Fasanya, Temitope ^{[2
]}

Rocha, Sonia ^{[2
]}

机构：

[1] Univ Dundee, Sch Life Sci, Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

[2] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Mol Physiol & Cell Signalling, Liverpool L69 7ZB, Merseyside, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期

基金：

英国惠康基金;

关键词：

hypoxia; cell cycle; HIF; PHDs; 2-OGDs; mitosis; NF-KAPPA-B; INDUCIBLE FACTOR 1-ALPHA; TUMOR-GROWTH; C-MYC; TRANSCRIPTIONAL REGULATION; DIRECT PHOSPHORYLATION; PROLYL HYDROXYLASES; PROTEIN-KINASES; GENE-EXPRESSION; HUMAN CEP192;

D O I：

10.3390/ijms22094874

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

引用

页数：15

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