PPARδ, but not PPARα, activates PGC-lα gene transcription in muscle

被引：98

作者：

Hondares, Elayne

Pineda-Torra, Ines

Iglesias, Roser

Staels, Bart

Villarroya, Francesc

Giralt, Marta ^{[1
]}

机构：

[1] Univ Barcelona, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain

[2] Inst Pasteur, INSERM, U545, F-509019 Lille, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 354卷 / 04期

关键词：

PGC-l alpha; peroxisome proliferator-activated receptor-gamma coactivator-l alpha; PPAR delta; peroxisome proliferator-activated receptor; skeletal muscle; PGC-l alpha gene promoter;

D O I：

10.1016/j.bbrc.2007.01.092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PGC-1 alpha induces mitochondrial biogenesis in muscle and its activity has been related to insulin sensitization. Here, we report that fibrates induce PGC-1 alpha gene expression in muscle both in vivo and in vitro. However, only activation via PPAR delta but not PPAR alpha underlies this effect. PPAR delta induces PGC-1 alpha gene transcription through a PPAR-response element in the PGC-1 alpha promoter. Moreover, PGC-1 alpha coactivates the PPAR delta-responsiveness of its own gene. A further positive autoregulatory loop of control relies on the induction of PPAR6 expression by PGC-1 alpha. These data point to a distinct value of PPAR6 rather than PPAR alpha agonists in the improvement of oxidative metabolism in muscle. (c) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：1021 / 1027

页数：7

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