Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds

被引：25
作者：
Khabnadideh, S
Tan, CL
Croft, SL
Kendrick, H
Yardley, V
Gilbert, IH
机构：
[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales
[2] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Med, London WC1E 7HT, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(00)00196-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1237 / 1239
页数：3
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