Flexible Osteogenic Glue as an All-In-One Solution to Assist Fracture Fixation and Healing

被引:56
|
作者
Tang, Jincheng [1 ]
Xi, Kun [1 ]
Chen, Hao [2 ]
Wang, Lingjun [1 ]
Li, Dongya [1 ]
Xu, Yun [3 ,4 ]
Xin, Tianwen [1 ]
Wu, Liang [1 ]
Zhou, Yidi [1 ]
Bian, Jiang [1 ]
Cai, Zhengwei [2 ]
Yang, Huilin [1 ]
Deng, Lianfu [2 ]
Gu, Yong [1 ]
Cui, Wenguo [2 ]
Chen, Liang [1 ]
机构
[1] Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Shanghai Key Lab Prevent & Treatment Bone & Joint, Dept Orthopaed,Ruijin Hosp,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[3] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Pain Rehabil, 2901 Caolang Rd, Shanghai 200025, Peoples R China
[4] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Orthopaed Surg, 2901 Caolang Rd, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
comminuted fractures; flexible fixation; orthopedic adhesive; osteogenesis; MECHANICAL-PROPERTIES; BOND STRENGTH; ADHESIVE; HYDROGELS; CYANOACRYLATE; NANOPARTICLES; CYTOTOXICITY; DEXTRAN; VIVO; DEGRADATION;
D O I
10.1002/adfm.202102465
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Osteogenic glue that reproduces the natural bone composition represents the final frontier of orthopedic adhesives with the potential to revolutionize surgical strategies against comminuted fractures. However, it is difficult to achieve an all-in-one formula, which could provide flexible and reliable adhesiveness while avoiding interfering with or even promoting the healing of glued fractures. Herein, an osteogenic glue characterized by inorganic-in-organic integration between amine-modified mesoporous bioactive glass nanoparticles (AMBGN) and bioadhesive gelatin-dextran network (GelDex) is introduced as an all-in-one tool to flexibly adhere and splice bone fragments and subsequently guide fracture healing during degradation. Relying on such integration, a 4-fold improvement in cohesiveness is presented, followed by a nearly 5-fold enhancement in adhesive strength in ex vivo porcine bone samples. The reversible and re-adjustable adhesiveness also enables glue to effectively splice intricate fragments from highly comminuted fractures in the rabbit radius in an in vivo environment. Moreover, well-preserved organic-inorganic integrity during degradation of the glue guides sustained interfacial osteogenesis and achieve satisfying healing outcomes in glued fractures, as observed by the 2-fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. The current findings propose an all-in-one solution for the fixation of bone fragments during surgery.
引用
收藏
页数:16
相关论文
共 50 条
  • [1] All-in-one solution
    Jane's Airport Review, 2004, (MAY):
  • [2] 'All-in-one' tenter solution
    Owen, P
    AATCC REVIEW, 2002, 2 (03) : 57 - 57
  • [3] A self-healing hydrogel electrolyte towards all-in-one flexible supercapacitors
    Ma, Wen-Bin
    Zhu, Ke-Hu
    Ye, Shi-Fang
    Wang, Yao
    Guo, Lin
    Tao, Xue-Yu
    Guo, Li-Tong
    Fan, He-Liang
    Liu, Zhang-Sheng
    Zhu, Ya-Bo
    Wei, Xian-Yong
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 2021, 32 (15) : 20445 - 20460
  • [4] A self-healing hydrogel electrolyte towards all-in-one flexible supercapacitors
    Wen-Bin Ma
    Ke-Hu Zhu
    Shi-Fang Ye
    Yao Wang
    Lin Guo
    Xue-Yu Tao
    Li-Tong Guo
    He-Liang Fan
    Zhang-Sheng Liu
    Ya-Bo Zhu
    Xian-Yong Wei
    Journal of Materials Science: Materials in Electronics, 2021, 32 : 20445 - 20460
  • [5] A Flexible All-in-One Lithium-Sulfur Battery A Flexible All-in-One Lithium-Sulfur Battery
    Yao, Minjie
    Wang, Rui
    Zhao, Zifang
    Liu, Yue
    Niu, Zhiqiang
    Chen, Jun
    ACS NANO, 2018, 12 (12) : 12503 - 12511
  • [6] Recent advances in all-in-one flexible supercapacitors
    Guo, Tiezhu
    Zhou, Di
    Liu, Wenfeng
    Su, Jinzhan
    SCIENCE CHINA-MATERIALS, 2021, 64 (01) : 27 - 45
  • [7] A novel all-in-one integrated flexible supercapacitor based on self-healing hydrogel electrolyte
    Gao, Xiaojie
    Hu, Qinzheng
    Sun, Kanjun
    Peng, Hui
    Xie, Xuan
    Hamouda, Hamouda Adam
    Ma, Guofu
    JOURNAL OF ALLOYS AND COMPOUNDS, 2021, 888
  • [8] A novel all-in-one integrated flexible supercapacitor based on self-healing hydrogel electrolyte
    Gao, Xiaojie
    Hu, Qinzheng
    Sun, Kanjun
    Peng, Hui
    Xie, Xuan
    Hamouda, Hamouda Adam
    Ma, Guofu
    Journal of Alloys and Compounds, 2021, 888
  • [9] A Self-Healing and Sweat-Chargeable Hydrogel Electrolyte for All-in-One Flexible Supercapacitors
    Yang, Xu
    Cheng, Xinyue
    Liao, Shiqin
    Chen, Dongsheng
    Wei, Qufu
    ACS APPLIED MATERIALS & INTERFACES, 2024, 16 (37) : 49337 - 49348
  • [10] An all-in-one solution to geometric and photometric calibration
    Pilet, Julien
    Geiger, Andreas
    Lagger, Pascal
    Lepetit, Vincent
    Fua, Pascal
    2006 IEEE/ACM INTERNATIONAL SYMPOSIUM ON MIXED AND AUGMENTED REALITY, 2006, : 139 - 148