Flexible Osteogenic Glue as an All-In-One Solution to Assist Fracture Fixation and Healing

被引:56
|
作者
Tang, Jincheng [1 ]
Xi, Kun [1 ]
Chen, Hao [2 ]
Wang, Lingjun [1 ]
Li, Dongya [1 ]
Xu, Yun [3 ,4 ]
Xin, Tianwen [1 ]
Wu, Liang [1 ]
Zhou, Yidi [1 ]
Bian, Jiang [1 ]
Cai, Zhengwei [2 ]
Yang, Huilin [1 ]
Deng, Lianfu [2 ]
Gu, Yong [1 ]
Cui, Wenguo [2 ]
Chen, Liang [1 ]
机构
[1] Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Shanghai Key Lab Prevent & Treatment Bone & Joint, Dept Orthopaed,Ruijin Hosp,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[3] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Pain Rehabil, 2901 Caolang Rd, Shanghai 200025, Peoples R China
[4] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Orthopaed Surg, 2901 Caolang Rd, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
comminuted fractures; flexible fixation; orthopedic adhesive; osteogenesis; MECHANICAL-PROPERTIES; BOND STRENGTH; ADHESIVE; HYDROGELS; CYANOACRYLATE; NANOPARTICLES; CYTOTOXICITY; DEXTRAN; VIVO; DEGRADATION;
D O I
10.1002/adfm.202102465
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Osteogenic glue that reproduces the natural bone composition represents the final frontier of orthopedic adhesives with the potential to revolutionize surgical strategies against comminuted fractures. However, it is difficult to achieve an all-in-one formula, which could provide flexible and reliable adhesiveness while avoiding interfering with or even promoting the healing of glued fractures. Herein, an osteogenic glue characterized by inorganic-in-organic integration between amine-modified mesoporous bioactive glass nanoparticles (AMBGN) and bioadhesive gelatin-dextran network (GelDex) is introduced as an all-in-one tool to flexibly adhere and splice bone fragments and subsequently guide fracture healing during degradation. Relying on such integration, a 4-fold improvement in cohesiveness is presented, followed by a nearly 5-fold enhancement in adhesive strength in ex vivo porcine bone samples. The reversible and re-adjustable adhesiveness also enables glue to effectively splice intricate fragments from highly comminuted fractures in the rabbit radius in an in vivo environment. Moreover, well-preserved organic-inorganic integrity during degradation of the glue guides sustained interfacial osteogenesis and achieve satisfying healing outcomes in glued fractures, as observed by the 2-fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. The current findings propose an all-in-one solution for the fixation of bone fragments during surgery.
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页数:16
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