Neuromuscular complications of severe COVID-19 in paediatric patients: Medium-term follow-up

被引：2

作者：

Avila-Smirnow, Daniela ^{[1
,2
,6
]}

Cespedes, Pamela ^{[3
]}

Reyes, Felipe ^{[4
]}

Angulo, Jenniffer ^{[5
]}

Cavagnaro, Agustin ^{[3
]}

Wegner, Adriana ^{[3
]}

机构：

[1] Pontificia Univ Catolica Chile, Escuela Med, Div Pediat, Unidad Neurol Pediat, Diagonal Paraguay 362, Santiago 8330077, Chile

[2] Serv Pediat, Unidad Neurol, Complejo Asistencial Dr Sotero Rio,Ave Concha & T, Puente Alto 8207257, Chile

[3] Serv Pediat, Unidad Paciente Crit Pediat, Complejo Asistencial Dr Sotero Rio,Ave Concha, Puente Alto 8207257, Chile

[4] Serv Pediat, Unidad Infectol Pediat, Complejo Asistencial Dr Sotero Rio, Ave Concha &, Puente Alto 8207257, Chile

[5] Pontificia Univ Catolica Chile, Escuela Med, Ctr Invest Med, Dept Enfermedades Infecciosas Inmunol Pediat,Lab, Ave Libertador Bernardo OHiggins 340, Santiago 8331150, Chile

[6] Pontificia Univ Catolica Chile, Escuela Med, Div Pediat, Unidad Neurol Pediat, Diagonal Paraguay 362,Piso8, Santiago 8330077, Chile

来源：

NEUROMUSCULAR DISORDERS | 2022年 / 32卷 / 06期

关键词：

Brachial plexus neuropathies; COVID-19; Intensive care units; Neuromuscular manifestations; Peripheral nervous system; Severe acute respiratory syndrome;

D O I：

10.1016/j.nmd.2022.04.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromuscular complications in paediatric patients with severe coronavirus disease 2019 (COVID-19) are poorly characterised. However, adult patients with severe COVID-19 reportedly present with frequent neuromuscular complications that mainly include critical illness polyneuropathy (CIP), critical illness myopathy (CIM), and focal neuropathies. We examined the records of all paediatric patients with severe COVID-19 who were mechanically ventilated and experienced neuromuscular complications from our single tertiary centre between March 2020 and August 2021. During this period, 4/36 (11%) patients admitted to the paediatric ICU who were mechanically ventilated experienced neuromuscular complications (one CIM, two focal neuropathies, and one CIP associated with plexopathy). In three of them, the gamma genetic variant of SARS-CoV-2 was identified. At the 4-5 month follow-up, three of our patients exhibited slight clinical improvement. We conclude that paediatric patients with severe COVID-19 may present neuromuscular complications similar to adults (11%), and their medium-term prognosis seems unfavourable.(c) 2022 Elsevier B.V. All rights reserved.

引用

页码：486 / 492

页数：7

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