Transformation of Schiff bases derived from α-naphthaldehyde.: Synthesis, spectral data and biological activity of new-3-aryl-2-(α-naphtyl)-4-thiazolidinones and N-aryl-N-[1-(α-naphthyl)but-3-enyl]amines

被引：13

作者：

Kouznetsov, V

Rodríguez, W

Stashenko, E

Ochoa, C

Vega, C

Rolón, M

Pereira, DM

Escario, JA

Barrio, AG

机构：

[1] Ind Univ Santander, Lab Fine Organ Synth, CIBIMOL, Sch Chem, Bucaramanga, Colombia

[2] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[3] Univ Complutense Madrid, Fac Farm, Dept Parasitol, E-28040 Madrid, Spain

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 06期

关键词：

D O I：

10.1002/jhet.5570410624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New N-aryl substituted 2-(alpha-naphthyl)-4-thiazolidinones were prepared by the cyclocondensation of alpha-mercaptoacetic acid and corresponding N-(alpha-naphthyliden)anilines. The same starting materials were utilized to obtain a new series of N-aryl-N-[1-(alpha-naphthyl)but-3-enyl]amines, which was synthesized through an addition of the Grignard reagent (allylmagnesium bromide) to the double bond C=N of the aldimines. The antichagasic and trichomonacidal in vitro activity, as well as, the antifungal and cytotoxic properties of some of these compounds were evaluated.

引用

页码：995 / 999

页数：5

共 25 条

[1]

ANDERS CJ, 2001, BIOORG MED CHEM LETT, V11, P715

[2]

Aydogan F, 2001, B KOR CHEM SOC, V22, P476

[3] Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents [J].

Barreca, ML ;

Chimirri, A ;

De Luca, L ;

Monforte, AM ;

Monforte, P ;

Rao, A ;

Zappalà, M ;

Balzarini, J ;

De Clercq, E ;

Pannecouque, C ;

Witvrouw, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (13) :1793-1796

[4] STEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS [J].

BROWN, AD ;

COLVIN, EW .

TETRAHEDRON LETTERS, 1991, 32 (38) :5187-5190

[5]

CARDILE V, 2003, FARMACO, V58, P489

[6]

Desai S, 1999, HETEROCYCL COMMUN, V5, P385

[7]

DESAI S, 1999, ORIENT J CHEM, V15, P499

[8] SYNTHESIS AND ANTIHISTAMINIC ACTIVITY OF SOME THIAZOLIDIN-4-ONES [J].

DIURNO, MV ;

MAZZONI, O ;

PISCOPO, E ;

CALIGNANO, A ;

GIORDANO, F ;

BOLOGNESE, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (15) :2910-2912

[9]

Hadjipavlou-Litina D J, 1998, Drug Des Discov, V15, P199

[10] 4-Aryl(benzyl)amino-4-heteroarylbut-1-enes as building blocks in heterocyclic synthesis.: 4.: Synthesis of 4,6-dimethyl-5-nitro(amino)2-pyridylquinolines and their antiparasitic activities [J].

Kouznetsov, VV ;

Méndez, LYV ;

Tibaduiza, B ;

Ochoa, C ;

Pereira, DM ;

Ruiz, JJN ;

Portillo, CF ;

Serrano, SM ;

Barrio, AG ;

Bahsas, A ;

Amaro-Luis, J .

ARCHIV DER PHARMAZIE, 2004, 337 (03) :127-132

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