Doxycycline as a new chiral selector in capillary electrophoresis

被引：23

作者：

Jang, Min Gyeong ^{[1
]}

Jang, Myung Duk ^{[2
]}

Park, Jung Hag ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Chem, Gyongsan 38541, South Korea

[2] Kyungwoon Univ, Dept Mat & Energy Engn, Gumi 39160, South Korea

来源：

JOURNAL OF CHROMATOGRAPHY A | 2017年 / 1508卷

基金：

新加坡国家研究基金会;

关键词：

Capillary electrophoresis; Chiral selector; Doxycycline; Enantioseparation; BASIC DRUGS; MACROCYCLIC ANTIBIOTICS; ENANTIOMERIC SEPARATION; LIQUID-CHROMATOGRAPHY; RESOLUTION; ENANTIOSEPARATION; PHARMACEUTICALS; VANCOMYCIN; METHANOL;

D O I：

10.1016/j.chroma.2017.06.019

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Doxycycline (DOX) is one of the tetracycline class of antibiotics and has not been examined for its enantioseparation abilities previously. The purpose of the present work was to evaluate DOX as a chiral selector (CS) using capillary electrophoresis (CE) in nonaqueous mode. Systematic experiments were performed to investigate the effects of concentration of CS, compositions of organic solvents and background electrolytes, applied voltage on chiral separation of a set of acidic chiral compounds. Excellent resolutions of enantiomers of acidic chiral compounds were attained in a background electrolytes composed of 50:50 acetonitrile/methanol + 214mM acetic acid+ 63 mM triethylamine and 38 mM DOX. The results show that DOX is a viable chiral selector in CE for the enantioseparation of the type of chiral compounds investigated. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：176 / 181

页数：6

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