Long-term potentiation and the ageing brain

被引：137
作者：
Barnes, CA [1 ]
机构：
[1] Univ Arizona, Dept Psychol, Tucson, AZ 85724 USA
[2] Univ Arizona, Dept Neurol, Tucson, AZ 85724 USA
[3] Univ Arizona, ARL Div Neural Syst Memory & Aging, Tucson, AZ 85724 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2003年 / 358卷 / 1432期
关键词：
ageing; long-term potentiation; hippocampus; learning; memory;
D O I：
10.1098/rstb.2002.1244
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
引用
收藏
页码：765 / 772
页数：8
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