Long-term potentiation and the ageing brain

被引：137
作者：
Barnes, CA [1 ]
机构：
[1] Univ Arizona, Dept Psychol, Tucson, AZ 85724 USA
[2] Univ Arizona, Dept Neurol, Tucson, AZ 85724 USA
[3] Univ Arizona, ARL Div Neural Syst Memory & Aging, Tucson, AZ 85724 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2003年 / 358卷 / 1432期
关键词：
ageing; long-term potentiation; hippocampus; learning; memory;
D O I：
10.1098/rstb.2002.1244
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
引用
收藏
页码：765 / 772
页数：8
相关论文
共 56 条
[1]   Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway [J].
Bach, ME ;
Barad, M ;
Son, H ;
Zhuo, M ;
Lu, YF ;
Shih, R ;
Mansuy, I ;
Hawkins, RD ;
Kandel, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5280-5285
[2]   REGION-SPECIFIC AGE EFFECTS ON AMPA SENSITIVITY - ELECTROPHYSIOLOGICAL EVIDENCE FOR LOSS OF SYNAPTIC CONTACTS IN HIPPOCAMPAL FIELD CA1 [J].
BARNES, CA ;
RAO, G ;
FOSTER, TC ;
MCNAUGHTON, BL .
HIPPOCAMPUS, 1992, 2 (04) :457-468
[3]   PHYSIOLOGICAL COMPENSATION FOR LOSS OF AFFERENT SYNAPSES IN RAT HIPPOCAMPAL GRANULE CELLS DURING SENESCENCE [J].
BARNES, CA ;
MCNAUGHTON, BL .
JOURNAL OF PHYSIOLOGY-LONDON, 1980, 309 (DEC) :473-485
[4]   AN AGE COMPARISON OF THE RATES OF ACQUISITION AND FORGETTING OF SPATIAL INFORMATION IN RELATION TO LONG-TERM ENHANCEMENT OF HIPPOCAMPAL SYNAPSES [J].
BARNES, CA ;
MCNAUGHTON, BL .
BEHAVIORAL NEUROSCIENCE, 1985, 99 (06) :1040-1048
[5]   MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT [J].
BARNES, CA .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1979, 93 (01) :74-104
[6]   NORMAL AGING - REGIONALLY SPECIFIC CHANGES IN HIPPOCAMPAL SYNAPTIC TRANSMISSION [J].
BARNES, CA .
TRENDS IN NEUROSCIENCES, 1994, 17 (01) :13-18
[7]   Multistability of cognitive maps in the hippocampus of old rats [J].
Barnes, CA ;
Suster, MS ;
Shen, JM ;
McNaughton, BL .
NATURE, 1997, 388 (6639) :272-275
[8]   LTP induction threshold change in old rats at the perforant path-granule cell synapse [J].
Barnes, CA ;
Rao, G ;
Houston, FP .
NEUROBIOLOGY OF AGING, 2000, 21 (05) :613-620
[9]  
Barnes CA, 1980, PSYCHOBIOLOGY AGING, P253
[10]   Time- and space-resolved dynamic studies on ceramic and cementitious materials [J].
Barnes, P ;
Colston, S ;
Craster, B ;
Hall, C ;
Jupe, A ;
Jacques, S ;
Cockcroft, J ;
Morgan, S ;
Johnson, M ;
O'Connor, D ;
Bellotto, M .
JOURNAL OF SYNCHROTRON RADIATION, 2000, 7 :167-177
123456