Inflammatory diseases: Is ubiquitinated NEMO at the hub?

被引：33
作者：
Burns, KA [1 ]
Martinon, F [1 ]
机构：
[1] Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland
来源：
CURRENT BIOLOGY | 2004年 / 14卷 / 24期
关键词：
D O I：
10.1016/j.cub.2004.11.040
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many patients with Crohn's disease carry mutations in NOD2, a molecule that can both activate and attenuate the pro-inflammatory effects of NF-kappaB. Recent studies implicate NOD2-induced ubiquitination of the NF-kappaB regulator NEMO as a potential means of manipulating the NF-kappaB signal.
引用
收藏
页码：R1040 / R1042
页数：3
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