Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

被引：55

作者：

Tu, Shu-Fen ^{[1
]}

Liu, Rosa Huang ^{[2
]}

Cheng, Yuan-Bin ^{[1
,3
]}

Hsu, Yu-Ming ^{[1
]}

Du, Ying-Chi ^{[1
]}

El-Shazly, Mohamed ^{[1
,4
]}

Wu, Yang-Chang ^{[1
,5
,6
,7
]}

Chang, Fang-Rong ^{[1
,3
,8
,9
,10
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 80708, Taiwan

[2] Chung Shan Med Univ, Sch Nutr, Coll Hlth Care & Management, Taichung 40201, Taiwan

[3] Kaohsiung Med Univ, Res Ctr Nat Prod & New Drug, Kaohsiung 80708, Taiwan

[4] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Cairo 11566, Egypt

[5] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[6] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung 404, Taiwan

[7] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[8] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 80708, Taiwan

[9] Kaohsiung Med Univ, Coll Pharm, Res & Dev Ctr Chinese Herbal Med & New Drugs, Kaohsiung 80708, Taiwan

[10] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80708, Taiwan

来源：

MOLECULES | 2014年 / 19卷 / 12期

关键词：

Clinacanthus nutans; sulfur-containing compound; INHIBITS SUPEROXIDE-PRODUCTION; SULFUR-CONTAINING AMIDE; ENTADA-PHASEOLOIDES; HUMAN NEUTROPHILS;

D O I：

10.3390/molecules191220382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new sulfur-containing compounds, named clinamides A-C (1-3), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR.

引用

页码：20382 / 20390

页数：9

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