Salivary Metabolomics for Oral Cancer Detection: A Narrative Review

被引：18

作者：

Panneerselvam, Karthika ^{[1
]}

Ishikawa, Shigeo ^{[2
]}

Krishnan, Rajkumar ^{[3
]}

Sugimoto, Masahiro ^{[4
,5
]}

机构：

[1] Karpaga Vinayaga Inst Dent Sci, Dept Oral Pathol & Microbiol, GST Rd,Palayanoor PO, Kancheepuram 603308, Tamil Nadu, India

[2] Yamagata Univ, Fac Med, Dept Dent Oral & Maxillofacial Plast & Reconstruc, Yamagata 9909585, Japan

[3] SRM Dent Coll, Dept Oral Pathol, Chennai 600089, Tamil Nadu, India

[4] Tokyo Med Univ, Inst Med Res, Tokyo 1600022, Japan

[5] Keio Univ, Inst Adv Biosci, Yamagata 9970811, Japan

来源：

METABOLITES | 2022年 / 12卷 / 05期

关键词：

oral cancer; metabolomics; saliva; diagnosis; prognosis; machine learning; BREAST-CANCER; LIQUID-CHROMATOGRAPHY; POTENTIAL BIOMARKERS; DIAGNOSTIC-APPROACH; MASS-SPECTROMETRY; POLYAMINES; QUANTIFICATION; VALIDATION; DISEASE; PATIENT;

D O I：

10.3390/metabo12050436

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of low- or non-invasive screening tests for cancer is crucial for early detection. Saliva is an ideal biofluid containing informative components for monitoring oral and systemic diseases. Metabolomics has frequently been used to identify and quantify numerous metabolites in saliva samples, serving as novel biomarkers associated with various conditions, including cancers. This review summarizes the recent applications of salivary metabolomics in biomarker discovery in oral cancers. We discussed the prevalence, epidemiologic characteristics, and risk factors of oral cancers, as well as the currently available screening programs, in India and Japan. These data imply that the development of biomarkers by itself is inadequate in cancer detection. The use of current diagnostic methods and new technologies is necessary for efficient salivary metabolomics analysis. We also discuss the gap between biomarker discovery and nationwide screening for the early detection of oral cancer and its prevention.

引用

页数：14

共 98 条

[1]

Akram M, 2014, INT J PREVENTIVE MED, V5, P915

[2] Metabolomic Profiling of Biological Reference Materials using a Multiplatform High-Resolution Mass Spectrometric Approach [J].

Aristizabal-Henao, Juan J. ;

Lemas, Dominick J. ;

Griffin, Fmily K. ;

Costa, Kaylie Anne ;

Camacho, Camden ;

Bowden, John A. .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 32 (09) :2481-2489

[3] Elevated Polyamines in Saliva of Pancreatic Cancer [J].

Asai, Yasutsugu ;

Itoi, Takao ;

Sugimoto, Masahiro ;

Sofuni, Atsushi ;

Tsuchiya, Takayoshi ;

Tanaka, Reina ;

Tonozuka, Ryosuke ;

Honjo, Mitsuyoshi ;

Mukai, Shuntaro ;

Fujita, Mitsuru ;

Yamamoto, Kenjiro ;

Matsunami, Yukitoshi ;

Kurosawa, Takashi ;

Nagakawa, Yuichi ;

Kaneko, Miku ;

Ota, Sana ;

Kawachi, Shigeyuki ;

Shimazu, Motohide ;

Soga, Tomoyoshi ;

Tomita, Masaru ;

Sunamura, Makoto .

CANCERS, 2018, 10 (02)

[4] Association of Smokeless Tobacco Use and Oral Cancer: A Systematic Global Review and Meta-Analysis [J].

Asthana, Smita ;

Labani, Satyanarayana ;

Kailash, Uma ;

Sinha, Dhirendra N. ;

Mehrotra, Ravi .

NICOTINE & TOBACCO RESEARCH, 2019, 21 (09) :1162-1171

[5] Polyamine synthesis as a target of MYC oncogenes [J].

Bachmann, Andre S. ;

Geerts, Dirk .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (48) :18757-18769

[6] Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment [J].

Baima, Giacomo ;

Iaderosa, Giovanni ;

Citterio, Filippo ;

Grossi, Silvia ;

Romano, Federica ;

Berta, Giovanni N. ;

Buduneli, Nurcan ;

Aimetti, Mario .

METABOLOMICS, 2021, 17 (01)

[7] Metabolomics Reveals Elevated Macromolecular Degradation in Periodontal Disease [J].

Barnes, V. M. ;

Ciancio, S. G. ;

Shibly, O. ;

Xu, T. ;

Devizio, W. ;

Trivedi, H. M. ;

Guo, L. ;

Joensson, T. J. .

JOURNAL OF DENTAL RESEARCH, 2011, 90 (11) :1293-1297

[8] Global Metabolomic Analysis of Human Saliva and Plasma from Healthy and Diabetic Subjects, with and without Periodontal Disease [J].

Barnes, Virginia M. ;

Kennedy, Adam D. ;

Panagakos, Fotinos ;

Devizio, William ;

Trivedi, Harsh M. ;

Joensson, Thomas ;

Guo, Lining ;

Cervi, Shannon ;

Scannapieco, Frank A. .

PLOS ONE, 2014, 9 (08)

[9] Metabolic Features of Saliva in Breast Cancer Patients [J].

Bel'skaya, Lyudmila V. ;

Sarf, Elena A. ;

Solomatin, Denis V. ;

Kosenok, Victor K. .

METABOLITES, 2022, 12 (02)

[10] Oral cancer diagnosis and perspectives in India [J].

Borse V. ;

Konwar A.N. ;

Buragohain P. .

Sensors International, 2020, 1

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