Engagement in Mental Health Care is Associated with Higher Cumulative Drug Exposure and Adherence to Antiretroviral Therapy

被引：18

作者：

Coyle, Ryan P. ^{[1
]}

Schneck, Christopher D. ^{[2
]}

Morrow, Mary ^{[3
]}

Coleman, Stacey S. ^{[4
]}

Gardner, Edward M. ^{[5
]}

Zheng, Jia-Hua ^{[6
]}

Ellison, Lucas ^{[6
]}

Bushman, Lane R. ^{[6
]}

Kiser, Jennifer J. ^{[6
]}

Mawhinney, Samantha ^{[3
]}

Anderson, Peter L. ^{[6
]}

Castillo-Mancilla, Jose R. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Dept Med, Div Infect Dis, Anschutz Med Campus,12700 E 19th Ave,B168, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Dept Psychiat, Anschutz Med Campus, Aurora, CO 80045 USA

[3] Univ Colorado, Colorado Sch Publ Hlth, Dept Biostat & Informat, Anschutz Med Campus, Aurora, CO USA

[4] Duke Univ Hosp, Durham, NC USA

[5] Denver Hlth Med Ctr, Div Infect Dis, Denver, CO USA

[6] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO USA

来源：

AIDS AND BEHAVIOR | 2019年 / 23卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Tenofovir-diphosphate; Dried blood spots; Adherence; Antiretroviral therapy; Mental health; DRIED BLOOD SPOTS; TENOFOVIR-DIPHOSPHATE; MEDICATION ADHERENCE; SUBSTANCE USE; REAL-TIME; HIV; EMTRICITABINE; TRIPHOSPHATE; DEPRESSION; DISORDERS;

D O I：

10.1007/s10461-019-02441-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Mental health (MH) disorders are more prevalent among persons living with HIV compared to the general population, and may contribute to suboptimal adherence to antiretroviral therapy (ART). Tenofovir-diphosphate (TFV-DP), the phosphorylated anabolite of tenofovir (TFV), is a biomarker with a 17-day half-life in red blood cells. TFV-DP can be measured in dried blood spots (DBS) using liquid chromatography/tandem mass spectrometry (LC-MS/MS) to assess adherence and cumulative drug exposure to tenofovir disoproxil fumarate (TDF)-based ART. From a larger clinical cohort (N = 807), TFV-DP concentrations and a paired HIV viral load were available from 521 participants at their enrollment visit. We used multivariable linear regression to evaluate the association between TFV-DP in DBS and engagement in MH care. After adjusting for clinical covariates, participants with MH disorders who were engaged in MH care had 40% higher TFV-DP compared to participants with MH disorders who were not engaged in MH care (p < 0.001), and similar TFV-DP to participants without MH disorders (p = 0.219). Further research is needed to identify the mechanism(s) for these findings, with the goal of optimizing engagement and retention in MH care strategies to improve ART adherence and clinical outcomes in PLWH with MH disorders.

引用

页码：3493 / 3502

页数：10

共 44 条

[1] Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy [J].

Anderson, Peter L. ;

Liu, Albert Y. ;

Castillo-Mancilla, Jose R. ;

Gardner, Edward M. ;

Seifert, Sharon M. ;

McHugh, Cricket ;

Wagner, Theresa ;

Campbell, Kayla ;

Morrow, Mary ;

Ibrahim, Mustafa ;

Buchbinder, Susan ;

Bushman, Lane R. ;

Kiser, Jennifer J. ;

MaWhinney, Samantha .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (01)

[2] Statistics in epidemiology: The case-control study [J].

Breslow, NE .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1996, 91 (433) :14-28

[3] Tenofovir Diphosphate in Dried Blood Spots Is Strongly Associated With Viral Suppression in Individuals With Human Immunodeficiency Virus Infections [J].

Castillo-Mancilla, Jose R. ;

Morrow, Mary ;

Coyle, Ryan P. ;

Coleman, Stacey S. ;

Gardner, Edward M. ;

Zheng, Jia-Hua ;

Ellison, Lucas ;

Bushman, Lane R. ;

Kiser, Jennifer J. ;

Mawhinney, Samantha ;

Anderson, Peter L. .

CLINICAL INFECTIOUS DISEASES, 2019, 68 (08) :1335-1342

[4] Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring [J].

Castillo-Mancilla, Jose R. ;

Haberer, Jessica E. .

CURRENT HIV/AIDS REPORTS, 2018, 15 (01) :49-59

[5]

Castillo-Mancilla JR, 2015, AIDS RES HUM RETROV, V31, P428, DOI [10.1089/AID.2014.0229, 10.1089/aid.2014.0229]

[6]

Castillo-Mancilla JR, 2013, AIDS RES HUM RETROV, V29, P384, DOI [10.1089/aid.2012.0089, 10.1089/AID.2012.0089]

[7] Mind the Gap: Gaps in Antidepressant Treatment, Treatment Adjustments, and Outcomes among Patients in Routine HIV Care in a Multisite US Clinical Cohort [J].

Cholera, Rushina ;

Pence, Brian W. ;

Bengtson, Angela M. ;

Crane, Heidi M. ;

Christopoulos, Katerina ;

Cole, Steven R. ;

Fredericksen, Rob ;

Gaynes, Bradley N. ;

Heine, Amy ;

Mathews, W. Christopher ;

Mimiaga, Matthew J. ;

Moore, Richard ;

Napravnik, Sonia ;

O'Clerigh, Conall ;

Safren, Steven ;

Mugavero, Michael J. .

PLOS ONE, 2017, 12 (01)

[8] Interventions and approaches to integrating HIV and mental health services: a systematic review [J].

Chuah, Fiona Leh Hoon ;

Haldane, Victoria Elizabeth ;

Cervero-Liceras, Francisco ;

Ong, Suan Ee ;

Sigfrid, Louise A. ;

Murphy, Georgina ;

Watt, Nicola ;

Balabanova, Dina ;

Hogarth, Sue ;

Maimaris, Will ;

Otero, Laura ;

Buse, Kent ;

McKee, Martin ;

Piot, Peter ;

Perel, Pablo ;

Legido-Quigley, Helena .

HEALTH POLICY AND PLANNING, 2017, 32 :27-47

[9] Antiretroviral Therapy for the Prevention of HIV-1 Transmission [J].

Cohen, M. S. ;

Chen, Y. Q. ;

McCauley, M. ;

Gamble, T. ;

Hosseinipour, M. C. ;

Kumarasamy, N. ;

Hakim, J. G. ;

Kumwenda, J. ;

Grinsztejn, B. ;

Pilotto, J. H. S. ;

Godbole, S. V. ;

Chariyalertsak, S. ;

Santos, B. R. ;

Mayer, K. H. ;

Hoffman, I. F. ;

Eshleman, S. H. ;

Piwowar-Manning, E. ;

Cottle, L. ;

Zhang, X. C. ;

Makhema, J. ;

Mills, L. A. ;

Panchia, R. ;

Faesen, S. ;

Eron, J. ;

Gallant, J. ;

Havlir, D. ;

Swindells, S. ;

Elharrar, V. ;

Burns, D. ;

Taha, T. E. ;

Nielsen-Saines, K. ;

Celentano, D. D. ;

Essex, M. ;

Hudelson, S. E. ;

Redd, A. D. ;

Fleming, T. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (09) :830-839

[10] Antidepressant therapy can improve adherence to antiretroviral regimens among HIV-infected and depressed patients [J].

Dalessandro, Margherita ;

Conti, Chiara M. ;

Gambi, Francesco ;

Falasca, Katia ;

Doyle, Robert ;

Conti, Pio ;

Caciagli, Francesco ;

Fulcheri, Mario ;

Vecchiet, Jacopo .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2007, 27 (01) :58-61

← 1 2 3 4 5 →