No strong HLA association with MOG antibody disease in the UK population

被引：21

作者：

Grant-Peters, Melissa ^{[1
]}

Passos, Giordani Rodrigues Dos ^{[2
,3
,4
]}

Yeung, Hing-Yuen ^{[1
]}

Jacob, Anu ^{[5
]}

Huda, Saif ^{[5
]}

Leite, Maria Isabel ^{[2
]}

Dendrou, Calliope A. ^{[1
]}

Palace, Jacqueline ^{[2
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

[2] John Radcliffe Hosp, Dept Clin Neurol, Oxford OX3 9DS, England

[3] Pontifical Catholic Univ Rio Grande Porto Alegre, Brain Inst, Porto Alegre, RS, Brazil

[4] Pontifical Catholic Univ Rio Grande Porto Alegre, Dept Neurol, Porto Alegre, RS, Brazil

[5] NHS Fdn Trust, Walton Ctr, Liverpool, Merseyside, England

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2021年 / 8卷 / 07期

基金：

英国惠康基金;

关键词：

MULTIPLE-SCLEROSIS; OLIGODENDROCYTE; SPECTRUM;

D O I：

10.1002/acn3.51378

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Improvements in assays for detecting serum antibodies against myelin oligo-dendrocyte glycoprotein (MOG) have led to the appreciation of MOG-antibody-associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti-MOG antibody generation. A weak protective association of HLA-C*03:04 was observed (OR = 0.26, 95% CI = 0.10-0.71, p(c) = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.

引用

页码：1502 / 1507

页数：6

共 20 条

[1] Distinct HLA associations of LGI1 and CASPR2-antibody diseases [J].

Binks, Sophie ;

Varley, James ;

Lee, Wanseon ;

Makuch, Mateusz ;

Elliott, Katherine ;

Gelfand, Jeffrey M. ;

Jacob, Saiju ;

Leite, M. Isabel ;

Maddison, Paul ;

Chen, Mian ;

Geschwind, Michael D. ;

Grant, Eleanor ;

Sen, Arjune ;

Waters, Patrick ;

McCormack, Mark ;

Cavalleri, Gianpiero L. ;

Barnardo, Martin ;

Knight, Julian C. ;

Irani, Sarosh R. .

BRAIN, 2018, 141 :2263-2271

[2] HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population [J].

Bruijstens, Arlette L. ;

Wong, Yu Yi M. ;

van Pelt, Danielle E. ;

van der Linden, Pieter J. E. ;

Haasnoot, Geert W. ;

Hintzen, Rogier Q. ;

Claas, Frans H. J. ;

Neuteboom, Rinze F. ;

Wokke, Beatrijs H. A. .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2020, 7 (03)

[3] Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults The MOGADOR study [J].

Cobo-Calvo, Alvaro ;

Ruiz, Anne ;

Maillart, Elisabeth ;

Audoin, Bertrand ;

Zephir, Helene ;

Bourre, Bertrand ;

Ciron, Jonathan ;

Collongues, Nicolas ;

Brassat, David ;

Cotton, Francois ;

Papeix, Caroline ;

Durand-Dubief, Francoise ;

Laplaud, David ;

Deschamps, Romain ;

Cohen, Mikael ;

Biotti, Damien ;

Ayrignac, Xavier ;

Tilikete, Caroline ;

Thouvenot, Eric ;

Brochet, Bruno ;

Dulau, Cecile ;

Moreau, Thibault ;

Tourbah, Ayman ;

Lebranchu, Pierre ;

Michel, Laure ;

Lebrun-Frenay, Christine ;

Montcuquet, Alexis ;

Mathey, Guillaume ;

Debouverie, Marc ;

Pelletier, Jean ;

Labauge, Pierre ;

Derache, Nathalie ;

Coustans, Marc ;

Rollot, Fabien ;

De Seze, Jerome ;

Vukusic, Sandra ;

Marignier, Romain .

NEUROLOGY, 2018, 90 (21) :E1858-E1869

[4]

Geraldes R, 2018, NAT REV NEUROL, V14, P199, DOI 10.1038/nrneurol.2018.14

[5] Time to separate MOG-Ab-associated disease from AQP4-Ab-positive neuromyelitis optica spectrum disorder [J].

Hacohen, Yael ;

Palace, Jacqueline .

NEUROLOGY, 2018, 90 (21) :947-948

[6] The role of thymic tolerance in CNS autoimmune disease [J].

Handel, Adam E. ;

Irani, Sarosh R. ;

Hollander, Georg A. .

NATURE REVIEWS NEUROLOGY, 2018, 14 (12) :724-735

[7] The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody [J].

Hoeftberger, Romana ;

Guo, Yong ;

Flanagan, Eoin P. ;

Lopez-Chiriboga, A. Sebastian ;

Endmayr, Verena ;

Hochmeister, Sonja ;

Joldic, Damir ;

Pittock, Sean J. ;

Tillema, Jan Mendelt ;

Gorman, Mark ;

Lassmann, Hans ;

Lucchinetti, Claudia F. .

ACTA NEUROPATHOLOGICA, 2020, 139 (05) :875-892

[8] Clinical presentation and prognosis in MOG-antibody disease: a UK study [J].

Jurynczyk, Maciej ;

Messina, Silvia ;

Woodhall, Mark R. ;

Raza, Naheed ;

Everett, Rosie ;

Roca-Fernandez, Adriana ;

Tackley, George ;

Hamid, Shahd ;

Sheard, Angela ;

Reynolds, Gavin ;

Chandratre, Saleel ;

Hemingway, Cheryl ;

Jacob, Anu ;

Vincent, Angela ;

Leite, M. Isabel ;

Waters, Patrick ;

Palace, Jacqueline .

BRAIN, 2017, 140 :3128-3138

[9] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - THE BALANCE BETWEEN ENCEPHALITOGENIC LYMPHOCYTES-T AND DEMYELINATING ANTIBODIES DETERMINES SIZE AND STRUCTURE OF DEMYELINATED LESIONS [J].

LASSMANN, H ;

BRUNNER, C ;

BRADL, M ;

LININGTON, C .

ACTA NEUROPATHOLOGICA, 1988, 75 (06) :566-576

[10] Multiple sclerosis: experimental models and reality [J].

Lassmann, Hans ;

Bradl, Monika .

ACTA NEUROPATHOLOGICA, 2017, 133 (02) :223-244

← 1 2 →