Methodological Issues and Possible Clinical Implications for Exhaled Breath Condensate pH in Asthma

被引：6

作者：

Bikov, Andras ^{[1
]}

Horvath, Ildiko ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Dept Pulmonol, 1125,Dios Arok 1-C, H-1085 Budapest, Hungary

[2] Natl Koranyi Inst TB & Pulmonol, Budapest, Hungary

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 14期

关键词：

Airway acidity; Airway inflammation; Asthma; Breath test; Exhaled breath condensate; Exhaled breath condensate pH; OBSTRUCTIVE SLEEP-APNEA; ACID-BASE-EQUILIBRIUM; AIRWAY INFLAMMATION; NITRIC-OXIDE; OXIDATIVE STRESS; CYSTIC-FIBROSIS; RESPIRATORY HEALTH; ATOPIC-DERMATITIS; LUNG-FUNCTION; INHALED CORTICOSTEROIDS;

D O I：

10.2174/1568026616666150930120421

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications.

引用

页码：1550 / 1560

页数：11

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