Structural heterogeneity in DNA gyrases from Gram-positive and Gram-negative bacteria

被引：0

作者：

Manjunatha, UH

Madhusudan, K

Visweswariah, SS

Nagaraja, V ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

来源：

CURRENT SCIENCE | 2000年 / 79卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GyraseA (GyrA) subunit of DNA gyrase from mycobacteria has certain characteristics distinct from that of E. coli. Polyclonal antibodies produced against M. tuberculosis GyrA recognized GyrA from different slow and fast growing mycobacterial species and also from several Gram-positive bacteria. However, these antibodies did not cross-react with E. coli GyrA and the enzyme from other Gram-negative bacteria. The results from the present study together with multiple alignment, pairwise comparison and biochemical properties support the idea of the occurrence of two subclasses of gyrases in the bacterial kingdom, emphasizing the importance of the enzyme as a molecular target for the development of novel therapeutics.

引用

页码：968 / 974

页数：7

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