Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors

被引：31

作者：

Patman, Joanne ^{[1
]}

Bhardwaj, Namrta ^{[1
]}

Ramnauth, Jailall ^{[1
]}

Annedi, Subhash C. ^{[1
]}

Renton, Paul ^{[1
]}

Maddaford, Shawn P. ^{[1
]}

Rakhit, Suman ^{[1
]}

Andrews, John S. ^{[1
]}

机构：

[1] NeurAxon Inc, Mississauga, ON L5J 2Z1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 09期

关键词：

nitric oxide synthase; nitric oxide; inhibitor; 2-aminobenzothiazole;

D O I：

10.1016/j.bmcl.2007.02.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 2-aminobenzothiazole compounds have been synthesized and evaluated as nitric oxide synthase (NOS) inhibitors. Compound 14 shows activity in the nM range and is selective for the human neuronal NOS isoform. We have also evaluated the compounds against the rat NOS isoforms. For some of the compounds, there are significant differences in NOS inhibitory activities between the human and rat enzymes. For example, compound 10b has nM activity against the rat nNOS while low mu M activity against the human nNOS. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2540 / 2544

页数：5

共 50 条

[1] Selective inhibitors of neuronal nitric oxide synthase
Silverman, Richard B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[2] Selective neuronal nitric oxide synthase inhibitors
Erdal, EP
Litzinger, EA
Seo, JW
Zhu, YQ
Ji, HT
Silverman, RB
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (07) : 603 - 624
[3] Novel inhibitors of neuronal nitric oxide synthase
Di Giacomo, C
Sorrenti, V
Salerno, L
Cardile, V
Guerrera, F
Siracusa, MA
Avitabile, M
Vanella, A
EXPERIMENTAL BIOLOGY AND MEDICINE, 2003, 228 (05) : 486 - 490
[4] NEURONAL SELECTIVE INHIBITORS OF NITRIC-OXIDE SYNTHASE
MACDONALD, JE
WALLACE, A
GENTILE, R
CATALANO, J
SHAKSESPEARE, W
MATZ, J
FEDORCHUCK, M
DECORY, T
RUSINIAK, L
GIER, L
MURRAY, R
MCCREEDY, S
KAMP, D
SALTZMAN, E
REIF, D
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 14 - MEDI
[5] Discovery of selective inhibitors of neuronal nitric oxide synthase for neuroprotection
Reif, DW
CNS DRUG REVIEWS, 2000, 6 : 39 - 39
[6] Discovery of potent and selective inhibitors of neuronal nitric oxide synthase
Ji, Haitao
Jing, Qing
Xue, Fengtian
Li, Huiying
Martasek, Pavel
Roman, Linda J.
Poulos, Thomas L.
Silverman, Richard B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[7] Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors
Erdal, Erik P.
Martasek, Pavel
Roman, Linda J.
Silverman, Richard B.
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (18) : 6096 - 6108
[8] Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors
Gómez-Vidal, JA
Martásek, P
Roman, LJ
Silverman, RB
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (03) : 703 - 710
[9] Selective Neuronal Nitric Oxide Synthase Inhibitors and the Prevention of Cerebral Palsy
Ji, Haitao
Tan, Sidhartha
Igarashi, Jotaro
Li, Huiying
Derrick, Matthew
Martasek, Pavel
Roman, Linda J.
Vasquez-Vivar, Jeannette
Poulos, Thomas L.
Silverman, Richard B.
ANNALS OF NEUROLOGY, 2009, 65 (02) : 209 - 217
[10] A new class of selective and potent inhibitors of neuronal nitric oxide synthase
Lowe, JA
Qian, WM
Volkmann, RA
Heck, S
Nowakowski, J
Nelson, R
Nolan, C
Liston, D
Ward, K
Zorn, S
Johnson, C
Vanase, M
Faraci, WS
Verdries, KA
Baxter, J
Doran, S
Sanders, M
Ashton, M
Whittle, P
Stefaniak, M
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (17) : 2569 - 2572

← 1 2 3 4 5 →