TRPV6 and prostate cancer:: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression

被引：89

作者：

Wissenbach, U

Niemeyer, B

Himmerkus, N

Fixemer, T

Bonkhoff, H

Flockerzi, V ^{[1
]}

机构：

[1] Univ Saarland, Fak Med, D-66421 Homburg, Germany

[2] Univ Saarland, Fak Med, Inst Allgemeine & Spezielle Pathol, D-66421 Homburg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 322卷 / 04期

关键词：

D O I：

10.1016/j.bbrc.2004.08.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Life expectancy for patients suffering from prostate cancer is inversely correlated with the degree of extraprostatic metastasis. In order to find pharmacological tools to treat this aggressive growth it is important to define targets whose expression not only correlates with the malignancy of the cancerous cells, but that are also amenable to pharmacological intervention. In this review, we would like to focus on the potential role of a distinct class of ion channels that may be involved in this process. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1359 / 1363

页数：5

共 29 条

[1] The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells [J].