Inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response

被引:51
作者
Zhuang, Chun-Lan [1 ]
Lin, Zhi-Jie [2 ]
Bi, Zhao-Feng [1 ]
Qiu, Ling-Xian [1 ]
Hu, Fang-Fang [1 ]
Liu, Xiao-Hui [1 ]
Lin, Bi-Zhen [2 ]
Su, Ying-Ying [1 ]
Pan, Hui-Rong [2 ]
Zhang, Tian-Ying [1 ]
Huang, Shou-Jie [1 ]
Hu, Yue-Mei [3 ]
Qiao, You-Lin [4 ]
Zhu, Feng-Cai [3 ]
Wu, Ting [1 ]
Zhang, Jun [1 ]
Xia, Ning-Shao [1 ]
机构
[1] Xiamen Univ, Strait Collaborat Innovat Ctr Biomed & Pharmaceut, State Key Lab Mol Vaccinol & Mol Diagnost, Natl Inst Diagnost & Vaccine Dev Infect Dis,Sch P, Xiamen, Peoples R China
[2] Xiamen Innovax Biotech CO Ltd, Xiamen, Peoples R China
[3] Publ Hlth Res Inst Jiangsu Prov, Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210000, Jiangsu, Peoples R China
[4] Chinese Acad Med Sci, Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing, Peoples R China
关键词
Inflammation; adverse reaction; recombinant vaccine; immune response; antibody; vaccine hesitancy;
D O I
10.1080/22221751.2021.1891002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Concerns about vaccine safety are an important reason for vaccine hesitancy, however, limited information is available on whether common adverse reactions following vaccination affect the immune response. Data from three clinical trials of recombinant vaccines were used in this post hoc analysis to assess the correlation between inflammation-related solicited adverse reactions (ISARs, including local pain, redness, swelling or induration and systematic fever) and immune responses after vaccination. In the phase III trial of the bivalent HPV-16/18 vaccine (Cecolin (R)), the geometric mean concentrations (GMCs) for IgG anti-HPV-16 and -18 (P<0.001) were significantly higher in participants with any ISAR following vaccination than in those without an ISAR. Local pain, induration, swelling and systemic fever were significantly correlated with higher GMCs for IgG anti-HPV-16 and/or anti-HPV-18, respectively. Furthermore, the analyses of the immunogenicity bridging study of Cecolin (R) and the phase III trial of a hepatitis E vaccine yielded similar results. Based on these results, we built a scoring model to quantify the inflammation reactions and found that the high score of ISAR indicates the strong vaccine-induced antibody level. In conclusion, this study suggests inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response.
引用
收藏
页码:365 / 375
页数:11
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