Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11

被引：48

作者：

Zhang, Li-Hua ^{[1
,2
]}

Feng, Bao-Min ^{[3
]}

Zhao, Yu-Qing ^{[1
,2
]}

Sun, Yi ^{[4
]}

Liu, Bing ^{[1
,2
]}

Liu, Fang ^{[1
,2
]}

Chen, Gang ^{[1
,2
]}

Bai, Jiao ^{[1
,2
]}

Hua, Hui-Ming ^{[1
,2
]}

Wang, Hai-Feng ^{[1
,2
]}

Pei, Yue-Hu ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[3] Dalian Univ, Sch Life Sci & Biotechnol, Dalian 116622, Peoples R China

[4] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Polyketide; Butenolide; Diphenyl ether; Benzophenone; Aspergillus flavipes; alpha-Glucosidase; ALPHA-GLUCOSIDASE INHIBITION; BUTYROLACTONE DERIVATIVES; TERREUS; METABOLITES; BIOCHEMISTRY;

D O I：

10.1016/j.bmcl.2015.12.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new polyketides including three new butenolides (1-3), one new diphenyl ether (4), and one new benzophenone (5), together with eleven known compounds (6-16) were isolated from a wetland fungus Aspergillus flavipes PJ03-11. Their structures were elucidated on the basis of detailed spectroscopic analysis. All the isolated compounds were tested for their a-glucosidase inhibitory activities. The results showed that compounds 1-3, 6, 7, 11, 15 and 16 exhibited stronger inhibitory activities than acarbose. And the preliminary structure-activity relationships of aspulvinone and diphenyl ether compounds on the a-glucosidase inhibitory activity were reported. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：346 / 350

页数：5

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